(S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide

Base Information

Chemical Name:(S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide
CAS No.:480444-15-3
Molecular Formula:C₁₄H₂₀N₂O₃S
Molecular Weight:296.39
Hs Code.:
UNII:BDN58RY3FV
Nikkaji Number:J1.850.124D
Mol file:480444-15-3.mol

Synonyms:480444-15-3;(S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide;(Methanesulfonamide,N-[2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methylphenyl]- );N-[2-[(4S)-4,5-Dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methylphenyl]methanesulfonamide;BDN58RY3FV;SCHEMBL502861;KCLDECJIUSCXOX-GFCCVEGCSA-N;N-{2-methyl-6-[(4S)-4-(propan-2-yl)-4,5-dihydro-1,3-oxazol-2-yl]phenyl}methanesulfonamide;MFCD31381703;AC-31765;E85223;A1-06765;(S)-N-(2-(4-Isopropyl-4,5-dihydrooxazol-2- yl)-6-methylphenyl) methanesulfonamide(EBH);N-[2-methyl-6-[(4S)-4-propan-2-yl-4,5-dihydro-1,3-oxazol-2-yl]phenyl]methanesulfonamide;Methanesulfonamide, N-[2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methylphenyl]-

Suppliers and Price of (S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 11 raw suppliers

Chemical Property of (S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:296.11946368
Heavy Atom Count:20
Complexity:467

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)C2=NC(CO2)C(C)C)NS(=O)(=O)C
Isomeric SMILES:CC1=C(C(=CC=C1)C2=N[C@H](CO2)C(C)C)NS(=O)(=O)C

Technology Process of (S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide

There total 5 articles about (S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871360-39-3
(S)-2-amino-N-(1-hydroxy-3-methylbutan-2-yl)-3-methylbenzamide

: 124-63-0
methanesulfonyl chloride

: 480444-15-3
(S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methane sulfonamide

Guidance literature:: With dmap; In pyridine; at 0 - 20 ℃;
DOI:10.1021/ol0269805

Reference yield:

: C₁₃H₂₀N₂O₂

: 124-63-0
methanesulfonyl chloride

: 480444-15-3
C₁₄H₂₀N₂O₃S

Guidance literature:: With pyridine; dmap; at -10 - 25 ℃; for 3h;

Reference yield:

: 5437-38-7
3-methyl-2-nitrobenzoic acid

: 480444-15-3
(S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methane sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 0 - 20 °C

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

3: H₂ / Pd/C / methanol; tetrahydrofuran / 48 h / 20 °C

4: 32.4 g / DMAP / pyridine / 0 - 20 °C

With dmap; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane;
DOI:10.1021/ol0269805