2-Pentanol, 3-[(triphenylmethyl)amino]-, (2S,3R)-

Base Information

• Chemical Name: 2-Pentanol, 3-[(triphenylmethyl)amino]-, (2S,3R)-
• CAS No.: 482615-41-8
• Molecular Formula: C24H27NO
• Molecular Weight: 345.484
• Mol file: 482615-41-8.mol

Synonyms:

Chemical Property of 2-Pentanol, 3-[(triphenylmethyl)amino]-, (2S,3R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pentanol, 3-[(triphenylmethyl)amino]-, (2S,3R)-

There total 3 articles about 2-Pentanol, 3-[(triphenylmethyl)amino]-, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-(trityl-amino)-butyraldehyde (482615-37-2) + methyllithium (917-54-4) → (2S,3R)-3-(trityl-amino)-pentan-2-ol (482615-41-8) + (2R,3R)-3-(trityl-amino)-pentan-2-ol

Guidance literature:

methyllithium; copper(I) bromide dimethylsulfide complex; In diethyl ether; at -70 - 20 ℃;

(R)-2-(trityl-amino)-butyraldehyde; In diethyl ether; at -70 ℃; for 2h;

With ammonium chloride; In diethyl ether; water; at -70 - 20 ℃; for 16h;

Reference yield:

trityl chloride (76-83-5) → (2S,3R)-3-(trityl-amino)-pentan-2-ol (482615-41-8) + (2R,3R)-3-(trityl-amino)-pentan-2-ol

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -45 °C / Inert atmosphere

2.2: 16 h / -40 - 20 °C / Inert atmosphere

3.1: copper(I) bromide dimethylsulfide complex / diethyl ether / -70 - 20 °C / Inert atmosphere

3.2: 2 h / -70 °C / Inert atmosphere

3.3: 16 h / -70 - 20 °C / Saturated solution

With oxalyl dichloride; copper(I) bromide dimethylsulfide complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; 2.1: Swern oxidation / 2.2: Swern oxidation;

DOI:10.1016/j.bmc.2011.08.051

Reference yield:

(R)-2-(trityl-amino)-butan-1-ol (176315-09-6) → (2S,3R)-3-(trityl-amino)-pentan-2-ol (482615-41-8) + (2R,3R)-3-(trityl-amino)-pentan-2-ol

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -45 °C / Inert atmosphere

1.2: 16 h / -40 - 20 °C / Inert atmosphere

2.1: copper(I) bromide dimethylsulfide complex / diethyl ether / -70 - 20 °C / Inert atmosphere

2.2: 2 h / -70 °C / Inert atmosphere

2.3: 16 h / -70 - 20 °C / Saturated solution

With oxalyl dichloride; copper(I) bromide dimethylsulfide complex; dimethyl sulfoxide; In diethyl ether; dichloromethane; 1.1: Swern oxidation / 1.2: Swern oxidation;

DOI:10.1016/j.bmc.2011.08.051

upstream raw materials:

(R)-2-(trityl-amino)-butyraldehyde

methyllithium

trityl chloride

(R)-2-(trityl-amino)-butan-1-ol

Downstream raw materials:

6-benzylamino-2-[(1R,2S)-1-ethyl-2-hydroxypropylamino]-9-isopropylpurine