Furo(3,2-b)(1,8)naphthyridine-7-carboxylic acid, 2,3,5,8-tetrahydro-5-ethyl-8-oxo-

Base Information

Chemical Name:Furo(3,2-b)(1,8)naphthyridine-7-carboxylic acid, 2,3,5,8-tetrahydro-5-ethyl-8-oxo-
CAS No.:73101-90-3
Molecular Formula:C₁₃H₁₂N₂O₄
Molecular Weight:260.249
Hs Code.:
DSSTox Substance ID:DTXSID60223379
Wikidata:Q83101822

Synonyms:2,3,5,8-Tetrahydro-5-ethyl-8-oxofuro(3,2-b)(1,8)naphthyridine-7-carboxylic acid;Furo(3,2-b)(1,8)naphthyridine-7-carboxylic acid, 2,3,5,8-tetrahydro-5-ethyl-8-oxo-;5-Aethyl-8-oxo-2,3,5,8-tetrahydrofuro(3,2-b)(1,8)naphthyridin-7-carbonsaeure [German];5-Ethyl-2,3,5,8-tetrahydro-8-oxofuro(3,2-b)(1,8)naphthyridine-7-carboxylic acid;73101-90-3;5-Aethyl-8-oxo-2,3,5,8-tetrahydrofuro(3,2-b)(1,8)naphthyridin-7-carbonsaeure;SCHEMBL11336174;DTXSID60223379;LS-70867

Suppliers and Price of Furo(3,2-b)(1,8)naphthyridine-7-carboxylic acid, 2,3,5,8-tetrahydro-5-ethyl-8-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Furo(3,2-b)(1,8)naphthyridine-7-carboxylic acid, 2,3,5,8-tetrahydro-5-ethyl-8-oxo-

Chemical Property:

Vapor Pressure:1.95E-10mmHg at 25°C
Boiling Point:490.5°C at 760 mmHg
Flash Point:250.4°C
Density:1.459g/cm³
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:260.07970687
Heavy Atom Count:19
Complexity:448

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN1C=C(C(=O)C2=CC3=C(CCO3)N=C21)C(=O)O

Technology Process of Furo(3,2-b)(1,8)naphthyridine-7-carboxylic acid, 2,3,5,8-tetrahydro-5-ethyl-8-oxo-

There total 30 articles about Furo(3,2-b)(1,8)naphthyridine-7-carboxylic acid, 2,3,5,8-tetrahydro-5-ethyl-8-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 81711-99-1
ethyl 5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylate

: 73101-90-3
5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid

Guidance literature:: With sodium hydroxide; at 100 ℃; for 1h;
DOI:10.1248/cpb.32.4914

Reference yield:

: 73101-87-8
5-ethyl-8-oxo-5,8-dihydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid

: 73101-90-3
5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; under 3040 Torr;
DOI:10.1248/cpb.32.4914

Reference yield:

: 73101-78-7
3-ethoxy-6-nitro-2-picoline

: 73101-90-3
5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 91 percent / H₂, 5percent Pd-C / ethanol

2: 85 percent / ethanol / 1 h / Heating

3: 85 percent / 1 h / Heating; Dowtherm

4: 87 percent / K₂CO₃ / dimethylformamide / 1 h / 90 - 100 °C

5: 89 percent / AlCl₃ / CH₂Cl₂ / Ambient temperature

6: 98 percent / K₂CO₃ / N,N-dimethyl-acetamide / 0.5 h / 110 °C

7: 95 percent / hexamethylphosphoric acid triamide / 11 h / 140 °C

8: 67 percent / 47percent HBr / 4 h / Heating

9: 90 percent / conc. H₂SO₄ / 14 h / Ambient temperature

10: H₂, 5percent Pd-C / methanol / 3040 Torr

With palladium on activated charcoal; aluminium trichloride; sulfuric acid; hydrogen bromide; hydrogen; potassium carbonate; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.32.4914