73101-87-8

Upstream product

• 73101-91-4 ethyl 5-ethyl-8-oxo-5,8-dihydrofuro<3,2-b><1,8>naphthyridine-7-carboxylate 
• 73101-86-7 5-ethyl-8-oxo-5,8-dihydrofuro<3,2-b><1,8>naphthyridine-2,7-dicarboxylic acid 
• 79905-33-2 ethyl 6-benzyloxy-7-(2-dimethylaminovinyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-83-4 ethyl 6-ethoxy-1-ethyl-7-formyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-84-5 ethyl 1-ethyl-7-formyl-6-hydroxy-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-82-3 ethyl 6-ethoxy-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-81-2 ethyl 6-ethoxy-4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate 
• 76671-22-2 ethyl 2,3-dibromo-3-(6-ethoxy-3-ethoxycarbonyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridin-7-yl)propionate 
• 95837-14-2 3-(6-ethoxy-3-ethoxycarbonyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridin-7-yl)acrylic acid 
• 83593-35-5 ethyl 6-benzyloxy-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-7-carboxylate 
• 76671-23-3 ethyl 7-(2-bromovinyl)-6-ethoxy-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 76868-21-8 ethyl 7-(2-bromovinyl)-1-ethyl-6-hydroxy-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-89-0 ethyl 3-chloro-5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylate 
• 95837-13-1 ethyl 1-ethyl-6-hydroxy-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 

Downstream Products

• 73101-90-3 5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of antimicrobial agents. VI. Studies on the synthesis of furo[3,2-b][1,8]naphthyridine derivatives

As a part of our search for new antibacterial agents, 5-ethyl-8-oxo-5,8-dihydrofuro[3,2-b][1,8]naphthyridine-7-carboxylic acid and its 2,3-dihydrofuro derivative, the 4-aza analogue of droxacin, were synthesized and their antibacterial activities were tested. Both compounds exhibited high antibacterial activities and a broad antibacterial spectrum. In an attempt to find a suitable method for industrial-scale synthesis of these compounds, several methods for the furan ring cyclization of 6,7-disubstituted 1,8-naphthyridine-3-carboxylate derivatives were compared.

Furonaphthyridine compounds

2,3,5,8-Tetrahydrofuro- and 5,8-dihydrofuro[3,2-b]-1,8-naphthyridine compounds of the formula (I) STR1 wherein R1 represents an alkyl group having 1 to 6 carbon atoms and M represents a hydrogen atom, an alkali metal or an alkaline earth metal having anti-bacterial activity.