2-(N-phenylaminooxy)-1-cyclohexanone

Base Information

• Chemical Name: 2-(N-phenylaminooxy)-1-cyclohexanone
• CAS No.: 484696-92-6
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• DSSTox Substance ID: DTXSID10469361
• Nikkaji Number: J1.803.052G
• Mol file: 484696-92-6.mol

Synonyms:2-(N-phenylaminooxy)-1-cyclohexanone;484696-92-6;SCHEMBL814580;DTXSID10469361;QFHNHNNRQVLGAS-UHFFFAOYSA-N

Chemical Property of 2-(N-phenylaminooxy)-1-cyclohexanone

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 205.110278721
• Heavy Atom Count: 15
• Complexity: 212

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(=O)C(C1)ONC2=CC=CC=C2

Technology Process of 2-(N-phenylaminooxy)-1-cyclohexanone

There total 7 articles about 2-(N-phenylaminooxy)-1-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + Nitrosobenzene (586-96-9) → 2-(N-phenylaminooxy)cyclohexanone (484696-92-6)

Guidance literature:

With rac-proline; In dimethyl sulfoxide;

DOI:10.1002/chem.200600526

Reference yield: 85.0%

C11H24OSi2 (227014-39-3) + Nitrosobenzene (586-96-9) → 2-(N-phenylaminooxy)cyclohexanone (484696-92-6)

Guidance literature:

With silver tetrafluoroborate; C₃₈H₂₅O₃P; cesium fluoride; In tetrahydrofuran; methanol; at -78 ℃; for 16h;

DOI:10.1002/anie.200705679

Reference yield: 52.0%

1-(1-Cyclohexen-1-yl)pyrrolidine (1125-99-1) + Nitrosobenzene (586-96-9) → 2-(N-phenylaminooxy)cyclohexanone (484696-92-6)

Guidance literature:

With acetic acid; In toluene; at -78 ℃; for 1h;

DOI:10.1021/ja0444637

upstream raw materials:

1-(Trimethylsilyloxy)cyclohexene

Nitrosobenzene

1-(1-Cyclohexen-1-yl)pyrrolidine

cyclohexanone

Downstream raw materials:

2-(phenylamino)cyclohex-2-en-1-one

cyclohexanone-2-ol