Synonyms:nitrosobenzene;nitrosobenzene, 14C-labeled
99%, *data from raw suppliers
Nitrosobenzene *data from reagent suppliers
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There total 222 articles about Nitrosobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 83.0%
Reference yield: 77.0%
Reference yield: 48.0%
The research study on DXP Synthase-Catalyzed C-N Bond Formation, which is crucial for the selective inhibitor design targeting the enzyme DXP synthase. The purpose of the study was to understand the substrate specificity of DXP synthase, particularly its affinity for aromatic nitroso substrates, and to explore its potential as a drug target for anti-infective agents. The researchers discovered that DXP synthase has a high affinity for aromatic nitroso substrates, which are more reactive than their aldehyde counterparts, and that it can catalyze the formation of C-N bonds to generate aromatic hydroxamic acids or amides. They also found that DXP synthase has a larger active site compared to related enzymes like pyruvate dehydrogenase (PDH), which allows it to accommodate sterically demanding substrates. The study concluded that incorporating aryl acceptor substrate mimics into unnatural bisubstrate analogues could lead to selective inhibitors of DXP synthase. Key chemicals used in the process include 1-deoxy-d-xylulose 5-phosphate (DXP), pyruvate, d-glyceraldehyde 3-phosphate (d-GAP), thiamin diphosphate (ThDP), and various aromatic nitroso substrates such as nitrosobenzene and nitrosonaphthols. The researchers also synthesized benzylacetylphosphonate (BnAP) as a potential selective inhibitor of DXP synthase, demonstrating its effectiveness in inhibiting the enzyme with higher selectivity compared to PDH.
The study presents a method for the direct α-hydroxylation of cyclic α-branched ketones using Br?nsted acid mediation. The key chemicals involved are nitrosobenzene, which serves as the oxidant, and trichloroacetic acid (TCA), which acts as the Br?nsted acid catalyst. These reagents facilitate a tandem aminoxylation/N–O bond-cleavage process, leading to the formation of α-hydroxy carbonyl compounds, which are prevalent in pharmaceuticals and natural products. The study demonstrates that various α-aryl and α-alkyl cyclohexanones can be converted into the corresponding α-hydroxy ketones in moderate to good yields, showcasing the method's scope and potential applications in chemical synthesis.
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