2-(2-FLUORO-4-METHYLTHIAZOL-5-YL)ETHANOL

Base Information

• Chemical Name: 2-(2-FLUORO-4-METHYLTHIAZOL-5-YL)ETHANOL
• CAS No.: 69243-03-4
• Molecular Formula: C₆H₈FNOS
• Molecular Weight: 161.2
• Mol file: 69243-03-4.mol

Synonyms:NSC 208719

Chemical Property of 2-(2-FLUORO-4-METHYLTHIAZOL-5-YL)ETHANOL

Chemical Property:

• Vapor Pressure: 0.00109mmHg at 25°C
• Boiling Point: 288.3°C at 760 mmHg
• Flash Point: 128.1°C
• PSA: 61.36000
• Density: 1.311g/cm³
• LogP: 1.12540

Purity/Quality:

99% ^*data from raw suppliers

2-(2-FLUORO-4-METHYLTHIAZOL-5-YL)ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-FLUORO-4-METHYLTHIAZOL-5-YL)ETHANOL

There total 3 articles about 2-(2-FLUORO-4-METHYLTHIAZOL-5-YL)ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

2-amino-5-(2-hydroxyethyl)-4-methylthiazole (1820-94-6) → 2-fluoro-5-(2-hydroxyethyl)-4-methylthiazole (69243-03-4)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; for 4h; Irradiation;

Reference yield:

1-acetoxy-2-(2-fluoro-4-methyl-thiazol-5-yl)-ethane (69242-99-5) → 2-fluoro-5-(2-hydroxyethyl)-4-methylthiazole (69243-03-4)

Guidance literature:

With potassium hydrogencarbonate; In methanol;

DOI:10.1021/jm00189a017

Reference yield:

5-(2-acetoxy-ethyl)-4-methyl-thiazole-2-diazonium; tetrafluoroborate → 2-fluoro-5-(2-hydroxyethyl)-4-methylthiazole (69243-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 1 h / 65 °C

2: aq. KHCO₃ / methanol

With potassium hydrogencarbonate; In methanol; toluene;

DOI:10.1021/jm00189a017

upstream raw materials:

1-acetoxy-2-(2-fluoro-4-methyl-thiazol-5-yl)-ethane

2-amino-5-(2-hydroxyethyl)-4-methylthiazole

Refernces