Carbamic acid, [(3S)-1-(methylamino)-2-oxo-3-azetidinyl]-, 1,1-dimethylethyl

Base Information

Chemical Name:Carbamic acid, [(3S)-1-(methylamino)-2-oxo-3-azetidinyl]-, 1,1-dimethylethyl
CAS No.:485831-53-6
Molecular Formula:C₉H₁₇N₃O₃
Molecular Weight:215.252
Hs Code.:
Mol file:485831-53-6.mol

Synonyms:((S)-1-Methylamino-2-oxo-azetidin-3-yl)-carbamic acid tert-butyl ester;

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Chemical Property of Carbamic acid, [(3S)-1-(methylamino)-2-oxo-3-azetidinyl]-, 1,1-dimethylethyl

Chemical Property:

Melting Point:158 - 159.5 °C
PKA:10.78±0.20(Predicted)
PSA：70.67000
Density:1.17±0.1 g/cm3(Predicted)
LogP:0.57600

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Technology Process of Carbamic acid, [(3S)-1-(methylamino)-2-oxo-3-azetidinyl]-, 1,1-dimethylethyl

There total 2 articles about Carbamic acid, [(3S)-1-(methylamino)-2-oxo-3-azetidinyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 485831-41-2
1-[(N-methyl-N-benzyloxycarbonyl)amino]-3-[(tert-butoxycarbonyl)amino]-2-azetidinone

: 485831-53-6
1-[(N-methyl)amino]-3-[(tert-butoxycarbonyl)amino]-2-azetidinone

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h;
DOI:10.1021/jo026280d

Reference yield:

: 485831-39-8
N'-(2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-N-methyl-hydrazinecarboxylic acid benzyl ester

: 485831-53-6
1-[(N-methyl)amino]-3-[(tert-butoxycarbonyl)amino]-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / PPh₃; DBAD / tetrahydrofuran / 20 °C

2: 100 percent / H₂ / Pd/C / methanol / 2 h

With dibenzyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; 1: Mitsunobu reaction;
DOI:10.1021/jo026280d