Ethyl 4-[2-chloro-2-(4-chlorophenyl)ethyl]-1-piperazinecarboxylate

Base Information

Chemical Name:Ethyl 4-[2-chloro-2-(4-chlorophenyl)ethyl]-1-piperazinecarboxylate
CAS No.:486439-09-2
Molecular Formula:C15H20Cl2N2O2
Molecular Weight:331.242
Hs Code.:
DSSTox Substance ID:DTXSID801164265

Synonyms:DTXSID801164265;Ethyl 4-[2-chloro-2-(4-chlorophenyl)ethyl]-1-piperazinecarboxylate;486439-09-2

Suppliers and Price of Ethyl 4-[2-chloro-2-(4-chlorophenyl)ethyl]-1-piperazinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 4-[2-chloro-2-(4-chlorophenyl)ethyl]-1-piperazinecarboxylate

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:330.0901833
Heavy Atom Count:21
Complexity:328

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)N1CCN(CC1)CC(C2=CC=C(C=C2)Cl)Cl

Technology Process of Ethyl 4-[2-chloro-2-(4-chlorophenyl)ethyl]-1-piperazinecarboxylate

There total 4 articles about Ethyl 4-[2-chloro-2-(4-chlorophenyl)ethyl]-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 486439-07-0
4-[2-(4-chloro-phenyl)-2-hydroxy-ethyl]-piperazine-1-carboxylic acid ethyl ester

: 486439-09-2
4-[2-chloro-2-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid ethyl ester

Guidance literature:: With thionyl chloride; In dichloromethane; at 0 - 25 ℃;
DOI:10.1021/jm0255522

Reference yield:

: 120-43-4
4-ethoxycarbonylpiperazine

: 486439-09-2
4-[2-chloro-2-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂ / 0 - 25 °C

2: NaBH₄ / ethanol / 0 - 25 °C

3: SOCl₂ / CH₂Cl₂ / 0 - 25 °C

With sodium tetrahydroborate; thionyl chloride; TEA; In ethanol; dichloromethane;
DOI:10.1021/jm0255522

Reference yield:

: 486439-05-8
4-[2-(4-chloro-phenyl)-2-oxo-ethyl]-piperazine-1-carboxylic acid ethyl ester

: 486439-09-2
4-[2-chloro-2-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / ethanol / 0 - 25 °C

2: SOCl₂ / CH₂Cl₂ / 0 - 25 °C

With sodium tetrahydroborate; thionyl chloride; In ethanol; dichloromethane;
DOI:10.1021/jm0255522