Sitagliptin N-Boc IMpurity

Base Information

Chemical Name:Sitagliptin N-Boc IMpurity
CAS No.:486460-23-5
Molecular Formula:C21H23F6N5O3
Molecular Weight:507.436
Hs Code.:
Mol file:486460-23-5.mol

Synonyms:N-Boc-Sitagliptin;

Suppliers and Price of Sitagliptin N-Boc IMpurity

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Boc-Sitagliptin
25mg
$ 180.00

Alichem
(R)-tert-Butyl(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
5g
$ 816.00

Total 65 raw suppliers

Chemical Property of Sitagliptin N-Boc IMpurity

Chemical Property:

Melting Point:188-191 °C(Solv: toluene (108-88-3))
PKA:11.60±0.46(Predicted)
PSA：92.84000
Density:1.46±0.1 g/cm3(Predicted)
LogP:3.72480
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly, Heated), DMSO (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

N-Boc-Sitagliptin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-Boc-Sitagliptin is the N-Boc protected derivative of Sitagliptin (S490990), a dipeptidyl peptidase-4 inhibitor that is used for glycemic control for patients with type 2 diabetes.

Technology Process of Sitagliptin N-Boc IMpurity

There total 105 articles about Sitagliptin N-Boc IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 762240-92-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

: 486460-23-5
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 55 - 60 ℃; for 12h;

Reference yield: 99.0%

: 486460-21-3
3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 486460-23-5
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: With (2-iodo-5-methoxyphenyl)boronic acid; 4-(dimethylamino)pyridine N-oxide; In fluorobenzene; for 40h; Reagent/catalyst; Catalytic behavior;
DOI:10.1039/c5sc03761a