Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Base Information Edit

Chemical Name:Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-
CAS No.:881995-69-3
Molecular Formula:C11H12F3NO2
Molecular Weight:247.217
Hs Code.:
Mol file:881995-69-3.mol

Synonyms:Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-;(R)-Sitagliptin Methyl-Ester IMpurity;(3R)-3-aMino-4-(2,4,5-trifluorophenyl)butanoate;(R)-Methyl 3-aMino-4-(2,4,5-trifluoro phenyl) butanoate;Methyl (R)-b-Amino-2,4,5-F3-benzenebutanoate HCl

Suppliers and Price of Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
Methyl(R)-b-Amino-2,4,5-F3-benzenebutanoateHCl 97%
1g
$ 128.33

Total 25 raw suppliers

Chemical Property of Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- Edit

Chemical Property:

Boiling Point:316.0±42.0 °C(Predicted)
PKA:6.90±0.10(Predicted)
PSA：52.32000
Density:1.287±0.06 g/cm3(Predicted)
LogP:2.23710

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl(R)-b-Amino-2,4,5-F3-benzenebutanoateHCl 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

There total 20 articles about Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 67-56-1
methanol

: benzyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

: 881995-69-3
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Guidance literature:: With Ru(OAc)2((R)-dm-Segphos); ammonium acetate; hydrogen; salicylic acid; at 40 - 80 ℃; for 20h; Temperature; Catalytic behavior; Green chemistry;

Reference yield: 95.0%

: 1253055-94-5
(R)-(-)-mandelic acid salt of (R)-methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate

: 881995-69-3
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Guidance literature:: With sodium carbonate; In water; pH=8 - 9;

Reference yield: 68.0%

: methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

: 881995-69-3
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Guidance literature:: With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In 2,2,2-trifluoroethanol; at 50 ℃; for 40h; under 5171.62 Torr;
DOI:10.1016/j.bmcl.2007.01.111