4-[(4-methylphenyl)sulfonyl]-2,6-diphenylmorpholine

Base Information

• Chemical Name: 4-[(4-methylphenyl)sulfonyl]-2,6-diphenylmorpholine
• CAS No.: 488785-29-1
• Molecular Formula: C23H23NO3S
• Molecular Weight: 393.507
• Mol file: 488785-29-1.mol

Synonyms:(2S,6R)-2,6-Diphenyl-4-(toluene-4-sulfonyl)-morpholine;(2R,6S)-2,6-diphenyl-4-tosylmorpholine;

Chemical Property of 4-[(4-methylphenyl)sulfonyl]-2,6-diphenylmorpholine

Chemical Property:

• Melting Point: 138 - 140 °C
• PSA: 54.99000
• LogP: 5.51720

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(4-methylphenyl)sulfonyl]-2,6-diphenylmorpholine

There total 16 articles about 4-[(4-methylphenyl)sulfonyl]-2,6-diphenylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N,N-diphenacyl-p-toluenesulfonamide (80884-48-6) → (2S*,6R*)-2,6-diphenyl-4-tosylmorpholine (488785-29-1)

Guidance literature:

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; diastereoselective reaction;

DOI:10.1002/ejoc.201403294

Reference yield: 80.0%

C23H23NO4S (1346694-77-6) → (2S*,6R*)-2,6-diphenyl-4-tosylmorpholine (488785-29-1)

Guidance literature:

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/jo201975b

Reference yield: 71.0%

N,N-bis-(2-hydroxy-2-phenyl-ethyl)-4-methyl-benzenesulfonamide → (2S*,6R*)-2,6-diphenyl-4-tosylmorpholine (488785-29-1)

Guidance literature:

With sodium hydride; p-toluenesulfonyl chloride; In dichloromethane; at 40 ℃; for 22h;

DOI:10.1016/j.tet.2004.10.008

upstream raw materials:

N-((S)-2-Hydroxy-2-phenyl-ethyl)-N-((R)-2-hydroxy-2-phenyl-ethyl)-4-methyl-benzenesulfonamide

toluene-4-sulfonamide

N-((R)-2-((S)-2-hydroxy-1-phenylethoxy)-2-phenylethyl)-4-methylbenzenesulfonamide

C₂₃H₂₃NO₄S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 488785-29-1 4-[(4-methylphenyl)sulfonyl]-2,6-diphenylmorpholine

Send

Send

Metric Ton KG G Pound L ML

Send

Send