3,5,19-Trioxa-4,20-disiladocos-8-en-16-one, 14-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-18-(2-hydroxyethyl)-2,2,7,9,13, 15,17,17,20,20,21,21-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-4,4-diphenyl-, (6S,7R,8Z,13S,14S,15R,18S)-

Base Information

• Chemical Name: 3,5,19-Trioxa-4,20-disiladocos-8-en-16-one, 14-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-18-(2-hydroxyethyl)-2,2,7,9,13, 15,17,17,20,20,21,21-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-4,4-diphenyl-, (6S,7R,8Z,13S,14S,15R,18S)-
• CAS No.: 488791-48-6
• Molecular Formula: C56H93NO6SSi3
• Molecular Weight: 992.68
• Mol file: 488791-48-6.mol

Synonyms:

Chemical Property of 3,5,19-Trioxa-4,20-disiladocos-8-en-16-one, 14-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-18-(2-hydroxyethyl)-2,2,7,9,13, 15,17,17,20,20,21,21-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-4,4-diphenyl-, (6S,7R,8Z,13S,14S,15R,18S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5,19-Trioxa-4,20-disiladocos-8-en-16-one, 14-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-18-(2-hydroxyethyl)-2,2,7,9,13, 15,17,17,20,20,21,21-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-4,4-diphenyl-, (6S,7R,8Z,13S,14S,15R,18S)-

There total 14 articles about 3,5,19-Trioxa-4,20-disiladocos-8-en-16-one, 14-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-18-(2-hydroxyethyl)-2,2,7,9,13, 15,17,17,20,20,21,21-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-4,4-diphenyl-, (6S,7R,8Z,13S,14S,15R,18S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(12Z,16E)-(3S,6R,7S,8S,14R,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one (488791-46-4) → (12Z,16E)-(3S,6R,7S,8S,14R,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one (488791-48-6)

Guidance literature:

With camphor-10-sulfonic acid;

DOI:10.1039/b312213c

Reference yield:

(6Z,10E)-(2S,8R,9S)-9-(tert-Butoxy-diphenyl-silanyloxy)-2,6,8,10-tetramethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dienal (488791-42-0) → (12Z,16E)-(3S,6R,7S,8S,14R,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one (488791-48-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / LDA

2: 67 percent / CSA

With camphor-10-sulfonic acid; lithium diisopropyl amide;

DOI:10.1039/b312213c

Reference yield:

(6Z,10E)-(2S,8R,9S)-9-(tert-Butoxy-diphenyl-silanyloxy)-2,6,8,10-tetramethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dien-1-ol (488791-40-8) → (12Z,16E)-(3S,6R,7S,8S,14R,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one (488791-48-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / PCC

2: 72 percent / LDA

3: 67 percent / CSA

With camphor-10-sulfonic acid; pyridinium chlorochromate; lithium diisopropyl amide;

DOI:10.1039/b312213c

upstream raw materials:

(12Z,16E)-(3S,6R,7S,8S,14R,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one

5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,2-dimethyl-pentanoic acid phenyl ester

3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-pentanoic acid phenyl ester

(6Z,10E)-(2S,8R,9S)-9-(tert-Butoxy-diphenyl-silanyloxy)-2,6,8,10-tetramethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dienal