1,2-Pyrrolidinedicarboxylic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(2-methoxy-2-oxoethyl)-, 1-(phenylmethyl) ester, (2S,3R,5R)-

Base Information

Chemical Name:1,2-Pyrrolidinedicarboxylic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(2-methoxy-2-oxoethyl)-, 1-(phenylmethyl) ester, (2S,3R,5R)-
CAS No.:490015-49-1
Molecular Formula:C22H33NO7Si
Molecular Weight:451.592
Hs Code.:

1,2-Pyrrolidinedicarboxylic acid,
3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(2-methoxy-2-oxoethyl)-,
1-(phenylmethyl) ester, (2S,3R,5R)-

Synonyms:

Suppliers and Price of 1,2-Pyrrolidinedicarboxylic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(2-methoxy-2-oxoethyl)-, 1-(phenylmethyl) ester, (2S,3R,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,2-Pyrrolidinedicarboxylic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(2-methoxy-2-oxoethyl)-, 1-(phenylmethyl) ester, (2S,3R,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(2-methoxy-2-oxoethyl)-, 1-(phenylmethyl) ester, (2S,3R,5R)-

There total 7 articles about 1,2-Pyrrolidinedicarboxylic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(2-methoxy-2-oxoethyl)-, 1-(phenylmethyl) ester, (2S,3R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 490015-43-5
(2R,4R,5R)-4-tert-butyldimethylsilyloxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)pyrrolidine

: 490015-49-1
(2S,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; at 20 ℃; for 3h;
DOI:10.1021/jo026499s

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 490015-49-1
(2S,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 693 mg / K₂CO₃ / ethyl acetate / 2 h / 20 °C

2: 80 percent / hydrochloric acid / methanol; H₂O / 1.5 h / 20 °C

3: 84 percent / imidazole / dimethylformamide / 12 h / 20 °C

4: 62 percent / acetic acid / tetrahydrofuran; H₂O / 24 h / 20 °C

5: sodium periodate; ruthenium(III) chloride hydrate / acetonitrile; CCl₄ / 3 h / 20 °C

With 1H-imidazole; hydrogenchloride; ruthenium trichloride; sodium periodate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo026499s

Reference yield:

: ((4aR,6R,7aR)-2,2-Dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-6-yl)-acetic acid methyl ester

: 490015-49-1
(2S,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 693 mg / K₂CO₃ / ethyl acetate / 2 h / 20 °C

2: 80 percent / hydrochloric acid / methanol; H₂O / 1.5 h / 20 °C

3: 84 percent / imidazole / dimethylformamide / 12 h / 20 °C

4: 62 percent / acetic acid / tetrahydrofuran; H₂O / 24 h / 20 °C

5: sodium periodate; ruthenium(III) chloride hydrate / acetonitrile; CCl₄ / 3 h / 20 °C

With 1H-imidazole; hydrogenchloride; ruthenium trichloride; sodium periodate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo026499s