(2R,4R,5R)-4-hydroxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)-isopropylidene ketal-pyrrolidine

Base Information

Chemical Name:(2R,4R,5R)-4-hydroxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)-isopropylidene ketal-pyrrolidine
CAS No.:490015-41-3
Molecular Formula:C₁₉H₂₅NO₆
Molecular Weight:363.411
Hs Code.:

Synonyms:(2R,4R,5R)-4-hydroxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)-isopropylidene ketal-pyrrolidine

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Chemical Property of (2R,4R,5R)-4-hydroxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)-isopropylidene ketal-pyrrolidine

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Technology Process of (2R,4R,5R)-4-hydroxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)-isopropylidene ketal-pyrrolidine

There total 2 articles about (2R,4R,5R)-4-hydroxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)-isopropylidene ketal-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: ((4aR,6R,7aR)-2,2-Dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-6-yl)-acetic acid methyl ester

: 490015-41-3
(2R,4R,5R)-4-hydroxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)-isopropylidene ketal-pyrrolidine

Guidance literature:: With potassium carbonate; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1021/jo026499s

Reference yield:

: ((4aR,6R,7aR)-5-Benzenesulfonyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-6-yl)-acetic acid methyl ester

: 490015-41-3
(2R,4R,5R)-4-hydroxy-5-hydroxymethyl-2-methoxycarbonylmethyl-1-(benzyloxycarbonyl)-isopropylidene ketal-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium naphthalenide / 1,2-dimethoxy-ethane; tetrahydrofuran / -78 °C

2: 693 mg / K₂CO₃ / ethyl acetate / 2 h / 20 °C

With sodium naphthalenide; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethyl acetate;
DOI:10.1021/jo026499s