2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-methoxy phenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,6-dihydro -, (6R)-

Base Information

Chemical Name:2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-methoxy phenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,6-dihydro -, (6R)-
CAS No.:490021-15-3
Molecular Formula:C34H54O6Si2
Molecular Weight:614.97
Hs Code.:

2H-Pyran-2-one,
6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-methoxy
phenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,6-dihydro
-, (6R)-

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Chemical Property of 2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-methoxy phenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,6-dihydro -, (6R)-

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Technology Process of 2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-methoxy phenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,6-dihydro -, (6R)-

There total 19 articles about 2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-methoxy phenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,6-dihydro -, (6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 490021-14-2
Acrylic acid (E)-(1R,4R,5R,7R)-1-allyl-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-4-triethylsilanyloxy-non-2-en-8-ynyl ester

: 490021-15-3
(R)-6-[(E)-(3R,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one

Guidance literature:: With titanium(IV) isopropylate; Grubbs catalyst first generation; In dichloromethane; Heating;
DOI:10.1021/ol020193q

Reference yield:

: 126121-12-8
(E)-1-Trimethylsilanyl-hexa-1,5-dien-3-ol

: 490021-15-3
(R)-6-[(E)-(3R,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 46 percent / t-BuOOH; D-(-)-DIPT; Ti(i-PrO)4 / CH₂Cl₂ / 6 h / -20 °C

2.1: i-Pr₂NH; n-BuLi; Bu₃SnH / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: 98 percent / I₂ / diethyl ether / 0.5 h / 0 °C

3.1: 100 percent / imidazole / dimethylformamide / 1.5 h / 20 °C

4.1: n-BuLi / tetrahydrofuran / 0.33 h / -78 °C

4.2: MgBr₂ / tetrahydrofuran / 0.5 h / -78 °C

4.3: 91 percent / tetrahydrofuran / 1 h / -78 - -50 °C

5.1: 98 percent / HF / methanol; acetonitrile; H₂O / 0.08 h / 0 °C

6.1: 85 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / 0 °C

7.1: 89 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

8.1: 83 percent / Ti(i-PrO)4 / (PCy₃)2RuCl₂(CHPh) / CH₂Cl₂ / Heating

With 1H-imidazole; 2,6-dimethylpyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; hydrogen fluoride; tri-n-butyl-tin hydride; D-(-)-diisopropyl tartrate; diisopropylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1021/ol020193q

Reference yield:

: 490021-08-4
(R)-1-((2R,3R)-3-Trimethylsilanyl-oxiranyl)-but-3-en-1-ol

: 490021-15-3
(R)-6-[(E)-(3R,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: i-Pr₂NH; n-BuLi; Bu₃SnH / tetrahydrofuran; hexane / 2 h / 0 °C

1.2: 98 percent / I₂ / diethyl ether / 0.5 h / 0 °C

2.1: 100 percent / imidazole / dimethylformamide / 1.5 h / 20 °C

3.1: n-BuLi / tetrahydrofuran / 0.33 h / -78 °C

3.2: MgBr₂ / tetrahydrofuran / 0.5 h / -78 °C

3.3: 91 percent / tetrahydrofuran / 1 h / -78 - -50 °C

4.1: 98 percent / HF / methanol; acetonitrile; H₂O / 0.08 h / 0 °C

5.1: 85 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / 0 °C

6.1: 89 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

7.1: 83 percent / Ti(i-PrO)4 / (PCy₃)2RuCl₂(CHPh) / CH₂Cl₂ / Heating

With 1H-imidazole; 2,6-dimethylpyridine; titanium(IV) isopropylate; n-butyllithium; hydrogen fluoride; tri-n-butyl-tin hydride; diisopropylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol020193q