2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-iodo-4-[(4- methoxyphenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5, 6-dihydro-, (6R)-

Base Information

Chemical Name:2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-iodo-4-[(4- methoxyphenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5, 6-dihydro-, (6R)-
CAS No.:381665-53-8
Molecular Formula:C34H53IO6Si2
Molecular Weight:740.867
Hs Code.:

2H-Pyran-2-one,
6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-iodo-4-[(4-
methoxyphenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,
6-dihydro-, (6R)-

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Chemical Property of 2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-iodo-4-[(4- methoxyphenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5, 6-dihydro-, (6R)-

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Technology Process of 2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-iodo-4-[(4- methoxyphenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5, 6-dihydro-, (6R)-

There total 31 articles about 2H-Pyran-2-one, 6-[(1E,3R,4R,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-iodo-4-[(4- methoxyphenyl)methoxy]-3-methyl-3-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5, 6-dihydro-, (6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 381665-52-7
(R)-6-[(E)-(3R,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-8-trimethylsilanyl-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one

: 381665-53-8
(R)-6-[(E)-(3R,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-8-iodo-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one

Guidance literature:: With N-iodo-succinimide; silver nitrate; In acetone;
DOI:10.1002/1521-3773(20011001)40:19<3667::AID-ANIE3667>3.0.CO;2-6

Reference yield: 83.0%

: 490021-15-3
(R)-6-[(E)-(3R,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one

: 381665-53-8
(R)-6-[(E)-(3R,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-8-iodo-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one

Guidance literature:: With N-iodo-succinimide; silver nitrate; In acetone; at 20 ℃; for 3h;
DOI:10.1021/ol020193q

Reference yield:

: 994-30-9
triethylsilyl chloride

: 381665-53-8
(R)-6-[(E)-(3R,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-8-iodo-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: imidazole / dimethylformamide

2.1: 89 percent / n-BuLi / tetrahydrofuran / -40 °C

3.1: PPTS / acetone; H₂O

3.2: 65 percent / MnO₂ / CH₂Cl₂

4.1: 70 percent / bis(trifluoroacetoxyiodobenzene) / methanol; H₂O

5.1: 83 percent / Ph₃CBF₄ / diethyl ether

6.1: 93 percent / (p-Me-C₆H₄-i-Pr)Ru[(R,R)-(-N(Ts)-CHPh-CHPh-NH-)] / propan-2-ol / 36 h

7.1: 80 percent / 2,6-lutidine / CH₂Cl₂

8.1: 95 percent / AgNO₃; NIS / acetone

With 1H-imidazole; 2,6-dimethylpyridine; N-iodo-succinimide; n-butyllithium; trityl tetrafluoroborate; pyridinium p-toluenesulfonate; silver nitrate; bis-[(trifluoroacetoxy)iodo]benzene; (1R,2R)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine-RuII-p-cymene; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1002/1521-3773(20011001)40:19<3667::AID-ANIE3667>3.0.CO;2-6