3-Anilinopropanohydrazide

Base Information

• Chemical Name: 3-Anilinopropanohydrazide
• CAS No.: 4916-20-5
• Molecular Formula: C9H13N3O
• Molecular Weight: 179.222
• DSSTox Substance ID: DTXSID40563604
• Nikkaji Number: J2.669.633J
• Wikidata: Q82448077
• Mol file: 4916-20-5.mol

Synonyms:3-Anilinopropanohydrazide;4916-20-5;3-anilinopropanehydrazide;CHEMBRDG-BB 4023493;3-(PHENYLAMINO)PROPANEHYDRAZIDE;SCHEMBL1627561;DTXSID40563604;MFCD00559632;AKOS005188808;BS-38063;CS-0365715;3-Anilinopropanehydrazide (non-preferred name)

Chemical Property of 3-Anilinopropanohydrazide

Chemical Property:

• Vapor Pressure: 4.69E-08mmHg at 25°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 179.105862047
• Heavy Atom Count: 13
• Complexity: 155

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NCCC(=O)NN

Technology Process of 3-Anilinopropanohydrazide

There total 5 articles about 3-Anilinopropanohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 3-(phenylamino)propanoate (21911-84-2) → 3-anilinopropionic acid hydrazide (4916-20-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 12h; Reflux;

Reference yield: 64.2%

N-phenyl-β-alanine (5652-38-0) → 3-anilinopropionic acid hydrazide (4916-20-5)

Guidance literature:

With hydrazine hydrate; In toluene; for 4h; Reflux;

DOI:10.3987/COM-08-11478

Reference yield:

aniline (62-53-3) → 3-anilinopropionic acid hydrazide (4916-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ruthenium trichloride / PEG 2000 / 15 h / 20 °C

2: hydrazine hydrate / ethanol / 12 h / 20 °C / Reflux

With ruthenium trichloride; hydrazine hydrate; In PEG 2000; ethanol; 1: Michael addition;

upstream raw materials:

methyl 3-(phenylamino)propanoate

aniline

N-phenyl-β-alanine

Downstream raw materials:

3-(phenylamino)-N-[(phenylcarbamoyl)amino]propanamide

3-[phenyl(phenylcarbamoyl)amino]-N-[(phenylcarbamoyl)amino]propanamide

3-[phenyl(phenylthiocarbamoyl)amino]-N-[(phenylthiocarbamoyl)amino]propanamide

N-(2,5-dimethyl-1H-pyrrol-1-yl)-3-(phenylamino)propanamide