8-Methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Base Information

Chemical Name:8-Methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
CAS No.:492468-98-1
Molecular Formula:C13H12N4O
Molecular Weight:240.264
Hs Code.:
DSSTox Substance ID:DTXSID801205885

Synonyms:492468-98-1;SCHEMBL2250839;LTVVHAZBEXVWHI-UHFFFAOYSA-N;DTXSID801205885;8-methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine;8-Methoxy-5-phenyl[1,2,4]triazolo[1,5-a]pyridin-2-amine

Suppliers and Price of 8-Methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-Methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:240.10111102
Heavy Atom Count:18
Complexity:282

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(N2C1=NC(=N2)N)C3=CC=CC=C3

Technology Process of 8-Methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

There total 4 articles about 8-Methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 492468-97-0
8-methoxy-5-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine

: 98-80-6
phenylboronic acid

: 492468-98-1
8-methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 80 ℃; for 1.5h;
DOI:10.1055/s-2003-40874

Reference yield:

: 10201-71-5
3-methoxypyridin-2-amine

: 492468-98-1
8-methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / dioxane

2: 78 percent / NH₂OH; DMAP / methanol; ethanol

3: 49 percent / KIO₃; H₂SO₄ / 4 h / 120 °C

4: Pd(dppf)*DCM; Na₂CO₃ / dioxane / 80 °C

With dmap; potassium iodate; Pd(dppf)*DCM; sulfuric acid; hydroxylamine; sodium carbonate; In 1,4-dioxane; methanol; ethanol; 4: Suzuki coupling;
DOI:10.2533/000942904777677542

Reference yield:

: 175965-65-8
8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

: 492468-98-1
8-methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / KIO₃; H₂SO₄ / 4 h / 120 °C

2: Pd(dppf)*DCM; Na₂CO₃ / dioxane / 80 °C

With potassium iodate; Pd(dppf)*DCM; sulfuric acid; sodium carbonate; In 1,4-dioxane; 2: Suzuki coupling;
DOI:10.2533/000942904777677542