2-amino-N-(2-methylphenyl)benzamide

Base Information

• Chemical Name: 2-amino-N-(2-methylphenyl)benzamide
• CAS No.: 4943-85-5
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40352176
• Nikkaji Number: J3.065.899J
• Wikidata: Q82129190
• ChEMBL ID: CHEMBL38743
• Mol file: 4943-85-5.mol

Synonyms:2-amino-N-(2-methylphenyl)benzamide;2-Amino-N-(o-tolyl)benzamide;4943-85-5;Benzamide, 2-amino-N-(2-methylphenyl)-;2-Amino-N-(2-methylphenyl)-benzamide;MFCD00578802;BENZAMIDE,2-AMINO-N-(2-METHYLPHENYL)-;Oprea1_694694;CHEMBL38743;SCHEMBL4642645;2-amino-N-(o-tolyl)-benzamide;DTXSID40352176;UOXHTELQAYPDBQ-UHFFFAOYSA-N;AMY42121;STK662593;AKOS000125830;SB79914;s11921;AS-10444;SY108500;CS-0038876;A871806

Chemical Property of 2-amino-N-(2-methylphenyl)benzamide

Chemical Property:

• PSA: 55.12000
• LogP: 3.48370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 226.110613074
• Heavy Atom Count: 17
• Complexity: 267

Purity/Quality:

99% ^*data from raw suppliers

2-AMINO-N-(2-METHYLPHENYL)BENZAMIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1NC(=O)C2=CC=CC=C2N

Technology Process of 2-amino-N-(2-methylphenyl)benzamide

There total 13 articles about 2-amino-N-(2-methylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-nitro-N-(2-tolyl)benzamide (2385-25-3) → 2-amino-N-(2-methylphenyl)benzamide (4943-85-5)

Guidance literature:

With tetrahydroxydiboron; 5%-palladium/activated carbon; water; In acetonitrile; at 50 ℃; for 24h;

DOI:10.1016/j.tet.2017.05.056

Reference yield: 87.0%

2-methylchlorobenzene (95-49-8) + anthranilic acid amide (28144-70-9,88-68-6) → 2-amino-N-(2-methylphenyl)benzamide (4943-85-5) + 2-(2-methylphenylamino)benzamide (95216-60-7)

Guidance literature:

With palladium diacetate; potassium carbonate; XPhos; In tert-butyl alcohol; at 110 ℃; for 17h;

DOI:10.1021/ja035483w

Reference yield: 83.0%

isatoic anhydride (118-48-9) + o-toluidine (95-53-4) → 2-amino-N-(2-methylphenyl)benzamide (4943-85-5)

Guidance literature:

With aqueous extract of mesocarp of fruit of Balanites roxburghii plant; at 60 ℃; for 0.333333h;

DOI:10.1039/c4ra09514f

upstream raw materials:

isatoic anhydride

o-toluidine

methaqualone

2-nitro-N-(2-tolyl)benzamide

Downstream raw materials:

2-((E)-Styryl)-3-o-tolyl-2,3-dihydro-1H-quinazolin-4-one

3-(2-methylphenyl)quinazolin-4(3H)-one

2-(4-Hydroxy-phenyl)-3-o-tolyl-2,3-dihydro-1H-quinazolin-4-one

2-(4-Hydroxy-3-methoxy-phenyl)-3-o-tolyl-2,3-dihydro-1H-quinazolin-4-one

Refernces

• 1、 -. "Method for reducing aromatic nitro into arylamine". Paragraph 0153-0156. . Retrieved 2020/07/15.
• 2、 Zhou, Yanmei,Zhou, Haifeng,Liu, Sensheng,Pi, Danwei,Shen, Guanshuo. "Water as a hydrogen source in palladium-catalyzed reduction and reductive amination of nitroarenes mediated by diboronic acid". . p. 3898 - 3904. Retrieved 2017/06/13.