2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-[4-[2-[(phenylsulfonyl)amino ]phenyl]-1-piperazinyl]ethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3S)-

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-[4-[2-[(phenylsulfonyl)amino ]phenyl]-1-piperazinyl]ethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3S)-
CAS No.:494782-62-6
Molecular Formula:C40H44ClN5O6S
Molecular Weight:758.338
Hs Code.:

2(1H)-Isoquinolinecarboxylic acid,
3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-[4-[2-[(phenylsulfonyl)amino
]phenyl]-1-piperazinyl]ethyl]amino]carbonyl]-3,4-dihydro-,
1,1-dimethylethyl ester, (3S)-

Synonyms:

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-[4-[2-[(phenylsulfonyl)amino ]phenyl]-1-piperazinyl]ethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3S)-

Chemical Property:

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Safty Information:

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Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-[4-[2-[(phenylsulfonyl)amino ]phenyl]-1-piperazinyl]ethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3S)-

There total 7 articles about 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-[4-[2-[(phenylsulfonyl)amino ]phenyl]-1-piperazinyl]ethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57292-44-1
N-Boc-D-(4-Cl)Phe-OH

: 494782-62-6
tert-butyl 3-{N-[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-(4-{2-[(phenylsulfonyl)-amino]phenyl}piperazinyl)ethyl]carbamoyl}(3S)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide

2: TFA / CH₂Cl₂

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.01.060

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 494782-62-6
tert-butyl 3-{N-[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-(4-{2-[(phenylsulfonyl)-amino]phenyl}piperazinyl)ethyl]carbamoyl}(3S)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: i-Pr₂NEt / 1,2-dichloro-ethane

2: TFA / CH₂Cl₂

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide

4: TFA / CH₂Cl₂

5: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.01.060

Reference yield:

: 170017-74-0
1-[1,1-dimethylethoxycarbonyl]-4-(2-aminophenyl)piperazine

: 494782-62-6
tert-butyl 3-{N-[(1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-(4-{2-[(phenylsulfonyl)-amino]phenyl}piperazinyl)ethyl]carbamoyl}(3S)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: i-Pr₂NEt / 1,2-dichloro-ethane

2: TFA / CH₂Cl₂

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide

4: TFA / CH₂Cl₂

5: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.01.060