1H-Indole-1-carboxylic acid, 3-[2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxo-3-phen ylpropyl]amino]-1-hydroxyethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 3-[2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxo-3-phen ylpropyl]amino]-1-hydroxyethyl]-, 1,1-dimethylethyl ester
CAS No.:494803-87-1
Molecular Formula:C30H39N3O6
Molecular Weight:537.656
Hs Code.:

1H-Indole-1-carboxylic acid,
3-[2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxo-3-phen
ylpropyl]amino]-1-hydroxyethyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1H-Indole-1-carboxylic acid, 3-[2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxo-3-phen ylpropyl]amino]-1-hydroxyethyl]-, 1,1-dimethylethyl ester

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Technology Process of 1H-Indole-1-carboxylic acid, 3-[2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxo-3-phen ylpropyl]amino]-1-hydroxyethyl]-, 1,1-dimethylethyl ester

There total 4 articles about 1H-Indole-1-carboxylic acid, 3-[2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxo-3-phen ylpropyl]amino]-1-hydroxyethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 37553-65-4
Boc-N-Me-Phe-OH

: 494803-85-9
3-(2-amino-1-hydroxy-ethyl)-indole-1-carboxylic acid tert-butyl ester

: 494803-87-1
3-{2-[2-(tert-butoxycarbonyl-methyl-amino)-3-phenyl-propionylamino]-1-hydroxy-ethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01602-7

Reference yield:

: 57476-50-3
1-tert-butoxycarbonyl-3-formylindole

: 494803-87-1
3-{2-[2-(tert-butoxycarbonyl-methyl-amino)-3-phenyl-propionylamino]-1-hydroxy-ethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EtNH₂; AcONH₄

2: H₂ / Pd/C / tetrahydrofuran

3: 98 percent / HOBT; EDC / dimethylformamide

With ammonium acetate; hydrogen; benzotriazol-1-ol; ethylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Henry reaction;
DOI:10.1016/S0040-4039(02)01602-7

Reference yield:

: 3-(1-hydroxy-2-nitro-ethyl)-indole-1-carboxylic acid tert-butyl ester

: 494803-87-1
3-{2-[2-(tert-butoxycarbonyl-methyl-amino)-3-phenyl-propionylamino]-1-hydroxy-ethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / tetrahydrofuran

2: 98 percent / HOBT; EDC / dimethylformamide

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01602-7