2-Thiophenecarboxamide, 3-amino-5-bromo-

Base Information

• Chemical Name: 2-Thiophenecarboxamide, 3-amino-5-bromo-
• CAS No.: 494833-79-3
• Molecular Formula: C5H5BrN2OS
• Molecular Weight: 221.077
• Mol file: 494833-79-3.mol

Synonyms:

Chemical Property of 2-Thiophenecarboxamide, 3-amino-5-bromo-

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxamide, 3-amino-5-bromo-

There total 9 articles about 2-Thiophenecarboxamide, 3-amino-5-bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl (5-bromo-2-carbamoylthiophen-3-yl)carbamate (494833-78-2) → 3-amino-5-bromothiophene-2-carboxyamide (494833-79-3)

Guidance literature:

With hydrogenchloride; water; In ethyl acetate; at 45 ℃; for 2h;

Reference yield: 78.0%

3-amino-5-bromothiophene-2-carboxylic acid (1244027-57-3) → 3-amino-5-bromothiophene-2-carboxyamide (494833-79-3)

Guidance literature:

3-amino-5-bromothiophene-2-carboxylic acid; With ammonium chloride; triethylamine; In N,N-dimethyl-formamide; for 0.166667h;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 96h; Product distribution / selectivity;

Reference yield: 76.0%

3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester (107818-55-3) → 3-amino-5-bromothiophene-2-carboxyamide (494833-79-3)

Guidance literature:

3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester; With sodium hydroxide; In methanol; water; at 70 ℃;

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; water; at 20 ℃;

DOI:10.1016/j.bmc.2017.04.044

upstream raw materials:

tert-butyl (5-bromo-2-carbamoylthiophen-3-yl)carbamate

3-amino-5-bromothiophene-2-carboxylic acid

3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester

Methyl 3-aminothiophene-2-carboxylate

Downstream raw materials:

5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide

6-(5-methyl-1H-pyrazol-4-yl)-2-(2-phenyl-1-pyrrolidin-1-ylethyl)thieno[3,2-d]pyrimidin-4(3H)-one

(9H-fluoren-9-yl)methyl (1-((5-bromo-2-carbamoylthiophen-3-yl)amino)-2-methyl-1-oxopropan-2-yl)carbamate

6-bromo-2-[phenyl(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3H)-one

Refernces

• 1、 Kurasawa, Osamu,Homma, Misaki,Oguro, Yuya,Miyazaki, Tohru,Mori, Kouji,Uchiyama, Noriko,Iwai, Kenichi,Ohashi, Akihiro,Hara, Hideto,Yoshida, Sei,Cho, Nobuo. "2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase". . p. 3658 - 3670. Retrieved 2017/06/13.
• 2、 -. "HETEROCYCLIC COMPOUND". Page/Page column 44. . Retrieved 2013/02/28.