5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide

Base Information

Chemical Name:5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide
CAS No.:1330783-38-4
Molecular Formula:C₁₇H₁₈BrN₃O₂S
Molecular Weight:408.319
Hs Code.:

Synonyms:5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide

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Chemical Property of 5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide

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Technology Process of 5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide

There total 5 articles about 5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 494833-79-3
3-amino-5-bromothiophene-2-carboxyamide

: 2912-62-1
α-chlorophenylacetyl chloride

: 1330783-38-4
5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide

Guidance literature:: 3-amino-5-bromothiophene-2-carboxyamide; α-chlorophenylacetyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

pyrrolidine; In tetrahydrofuran; at 70 ℃; for 1h;

With sodium hydroxide; In tetrahydrofuran; water; at 120 ℃; for 2h;

Reference yield:

: 107818-55-3
3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester

: 1330783-38-4
5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide; water; methanol / 70 °C

1.2: 0.08 h / 20 °C

1.3: 120 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

2.2: 1 h / 70 °C

2.3: 2 h / 120 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1330783-38-4
5-bromo-3-{[phenyl(pyrrolidin-1-yl)acetyl]amino}thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / acetonitrile / 0 - 20 °C / Cooling with ice

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: potassium carbonate; methanol / water / 2 h / 20 °C

4.1: sodium hydroxide / N,N-dimethyl-formamide; water; methanol / 70 °C

4.2: 0.08 h / 20 °C

4.3: 120 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

5.2: 1 h / 70 °C

5.3: 2 h / 120 °C

With pyridine; methanol; n-butyllithium; potassium carbonate; triethylamine; diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetonitrile;