3,5-dimethylfuran-2(5H)-one

Base Information

• Chemical Name: 3,5-dimethylfuran-2(5H)-one
• CAS No.: 5584-69-0
• Molecular Formula: C6H8O2
• Molecular Weight: 112.1265
• Mol file: 5584-69-0.mol

Synonyms:

Chemical Property of 3,5-dimethylfuran-2(5H)-one

Chemical Property:

• Vapor Pressure: 0.125mmHg at 25°C
• Boiling Point: 218.5°C at 760 mmHg
• Flash Point: 81.2°C
• Density: 1.042g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dimethylfuran-2(5H)-one

There total 46 articles about 3,5-dimethylfuran-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon monoxide (201230-82-2) + (Z)-4-iodopent-3-en-2-ol (74785-05-0) → 3,5-dimethylfuran-2(5H)-one (5584-69-0,59417-65-1,127418-12-6)

Guidance literature:

With potassium carbonate; hydrazine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 35 ℃; for 48h; under 1520 Torr;

DOI:10.1021/ja00532a034

Reference yield: 98.0%

Pent-3-yn-2-ol (57984-70-0,58072-60-9,90242-65-2,27301-54-8) + carbon monoxide (201230-82-2) → 3,5-dimethylfuran-2(5H)-one (5584-69-0,59417-65-1,127418-12-6)

Guidance literature:

With hydrogen; 1,4-di(diphenylphosphino)-butane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In dichloromethane; at 95 ℃; for 36h; under 41371.8 Torr;

DOI:10.1021/jo9703663

Reference yield: 95.0%

2,4-dimethyl-Δ3-γ-butyrolactone (3740-58-7) → (5α)-3,5-dimethyl-2-furanone (5584-69-0,59417-65-1,127418-12-6)

Guidance literature:

With C₁₉H₂₄N₂O₃; In dichloromethane; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ja205674x

upstream raw materials:

2,4-dimethyl-Δ3-γ-butyrolactone

carbon monoxide

(Z)-4-iodopent-3-en-2-ol

α-bromo-α-methyl-γ-valerolactone