Technology Process of Cyclopropanecarboxylic acid, 1-amino-2-(3-hydroxyphenyl)-, (1R-trans)- (9CI)
There total 16 articles about Cyclopropanecarboxylic acid, 1-amino-2-(3-hydroxyphenyl)-, (1R-trans)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; Amberlite IRA-400 OH; acetic acid; 3-methyl-phenol;
In
1,4-dioxane;
at 0 ℃;
for 4h;
Yield given;
DOI:10.1021/jm00086a009
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 70 percent / aq. NaOH, Aliquat 336 / CH2Cl2 / Ambient temperature
2: 89 percent / piperidine, acetic acid / toluene / Heating
3: 1.) NaH / 1.) DMSO, RT, 30 min, 2.) THF a) RT, 1 h, b) 50 - 60 deg C, 1 h
4: 95.6 percent / aq. NaOH / ethanol / 40 h / Ambient temperature
5: 77 percent / triethylamine, diphenyl phosphorylazide (DPPA) / 24 h / Heating
6: 90 percent / aq. NaOH / ethanol / Heating
7: 93 percent / acetone / 144 h / 0 °C
8: 1.) m-cresol, 4 N aq. HCl, 2.) 3percent aq. CH3COOH, Amberlite IRA-400 OH / dioxane / 4 h / 0 °C
With
piperidine; hydrogenchloride; sodium hydroxide; Amberlite IRA-400 OH; diphenyl phosphoryl azide; Aliquat 336; sodium hydride; acetic acid; 3-methyl-phenol; triethylamine;
In
1,4-dioxane; ethanol; dichloromethane; acetone; toluene;
DOI:10.1021/jm00086a009
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 89 percent / piperidine, acetic acid / toluene / Heating
2: 1.) NaH / 1.) DMSO, RT, 30 min, 2.) THF a) RT, 1 h, b) 50 - 60 deg C, 1 h
3: 95.6 percent / aq. NaOH / ethanol / 40 h / Ambient temperature
4: 77 percent / triethylamine, diphenyl phosphorylazide (DPPA) / 24 h / Heating
5: 90 percent / aq. NaOH / ethanol / Heating
6: 93 percent / acetone / 144 h / 0 °C
7: 1.) m-cresol, 4 N aq. HCl, 2.) 3percent aq. CH3COOH, Amberlite IRA-400 OH / dioxane / 4 h / 0 °C
With
piperidine; hydrogenchloride; sodium hydroxide; Amberlite IRA-400 OH; diphenyl phosphoryl azide; sodium hydride; acetic acid; 3-methyl-phenol; triethylamine;
In
1,4-dioxane; ethanol; acetone; toluene;
DOI:10.1021/jm00086a009