1,4-Piperidinedicarboxylic acid, 4-Methoxy-, 1-(1,1-diMethylethyl) 4-Methyl ester

Base Information

• Chemical Name: 1,4-Piperidinedicarboxylic acid, 4-Methoxy-, 1-(1,1-diMethylethyl) 4-Methyl ester
• CAS No.: 495415-08-2
• Molecular Formula: C13H23NO5
• Molecular Weight: 273.32500
• Hs Code.: 2933399090
• Mol file: 495415-08-2.mol

Synonyms:1-tert-Butyl 4-methyl 4-methoxypiperidine-1,4-dicarboxylate;

Chemical Property of 1,4-Piperidinedicarboxylic acid, 4-Methoxy-, 1-(1,1-diMethylethyl) 4-Methyl ester

Chemical Property:

• Boiling Point: 330.4±42.0 °C(Predicted)
• PKA: -3.24±0.40(Predicted)
• PSA: 65.07000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 1.51340

Purity/Quality:

99%min ^*data from raw suppliers

1-tert-Butyl4-methyl4-methoxypiperidine-1,4-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Piperidinedicarboxylic acid, 4-Methoxy-, 1-(1,1-diMethylethyl) 4-Methyl ester

There total 1 articles about 1,4-Piperidinedicarboxylic acid, 4-Methoxy-, 1-(1,1-diMethylethyl) 4-Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.87%

1-tert-butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate (495415-09-3) + methyl iodide (74-88-4) → O1-tert-butyl O4-methyl 4-methoxypiperidine-1,4-dicarboxylate (495415-08-2)

Guidance literature:

1-tert-butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; for 3h; Inert atmosphere;

Reference yield: 100.0%

O1-tert-butyl O4-methyl 4-methoxypiperidine-1,4-dicarboxylate (495415-08-2) → 4-methoxypiperidine-4-carboxylic acid methyl ester hydrochloride (1190314-13-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

O1-tert-butyl O4-methyl 4-methoxypiperidine-1,4-dicarboxylate (495415-08-2) + benzyl chloroformate (501-53-1,94274-21-2) → O1-benzyl O4-methyl 4-methoxypiperidine-1,4-dicarboxylate

Guidance literature:

O₁-tert-butyl O₄-methyl 4-methoxypiperidine-1,4-dicarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

benzyl chloroformate; With potassium carbonate; In 1,4-dioxane; water; at 20 ℃; for 2h;

upstream raw materials:

1-tert-butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate

methyl iodide

Downstream raw materials:

4-methoxypiperidine-4-carboxylic acid methyl ester hydrochloride

Refernces

• 1、 -. "HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS". Page/Page column 148; 275. . Retrieved 2020/06/05.