1-Pyrrolidinecarboxylic acid, 2-[4-(aminomethyl)-2-thiazolyl]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[4-(aminomethyl)-2-thiazolyl]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)-
CAS No.:496048-68-1
Molecular Formula:C22H32N4O5SSi
Molecular Weight:492.671
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[4-(aminomethyl)-2-thiazolyl]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,
(4-nitrophenyl)methyl ester, (2S,4R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[4-(aminomethyl)-2-thiazolyl]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[4-(aminomethyl)-2-thiazolyl]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)-

There total 8 articles about 1-Pyrrolidinecarboxylic acid, 2-[4-(aminomethyl)-2-thiazolyl]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-thiazol-2-yl]-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester

: 496048-68-1
(2S,4R)-2-(4-aminomethylthiazol-2-yl)-4-(tert-butyldimethylsilanyloxy)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: With hydrazine hydrate; In methanol; dichloromethane; at 60 ℃; for 5h;
DOI:10.1016/S0223-5234(02)01397-1

Reference yield:

: 2-[(2S,4R)-4-Hydroxy-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-2-yl]-thiazole-4-carboxylic acid ethyl ester

: 496048-68-1
(2S,4R)-2-(4-aminomethylthiazol-2-yl)-4-(tert-butyldimethylsilanyloxy)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 3.93 g / imidazole / dimethylformamide / 1.5 h / 20 °C

2: NaBH₄ / ethanol / 6 h / 0 °C

3: 4.11 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: dimethylformamide / 1 h / 100 °C

5: 1.36 g / hydrazine hydrate / CH₂Cl₂; methanol / 5 h / 60 °C

With 1H-imidazole; sodium tetrahydroborate; hydrazine hydrate; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(02)01397-1

Reference yield:

: (2S,4R)-4-Benzoyloxy-2-carbamoyl-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester

: 496048-68-1
(2S,4R)-2-(4-aminomethylthiazol-2-yl)-4-(tert-butyldimethylsilanyloxy)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: 94.7 percent / Lawesson's reagent / tetrahydrofuran / 2 h / Heating

2: 89.2 percent / ethanol / 20 h / 20 °C

3: KOH / methanol / 2 h / cooling

4: 3.93 g / imidazole / dimethylformamide / 1.5 h / 20 °C

5: NaBH₄ / ethanol / 6 h / 0 °C

6: 4.11 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

7: dimethylformamide / 1 h / 100 °C

8: 1.36 g / hydrazine hydrate / CH₂Cl₂; methanol / 5 h / 60 °C

With Lawessons reagent; 1H-imidazole; potassium hydroxide; sodium tetrahydroborate; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(02)01397-1