1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, ethyl ester, (1S)-

Base Information

Chemical Name:1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, ethyl ester, (1S)-
CAS No.:496062-47-6
Molecular Formula:C25H27NO4
Molecular Weight:405.494
Hs Code.:

Synonyms:

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Chemical Property of 1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, ethyl ester, (1S)-

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Technology Process of 1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, ethyl ester, (1S)-

There total 11 articles about 1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, ethyl ester, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 496061-80-4
ethyl [(1S)-5-hydroxy-2,3-dihydro-1H-inden-1-yl]acetate

: 17944-68-2
2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethanol

: 496062-47-6
ethyl {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetate

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;

Reference yield:

: 5111-70-6
5-methoxy-1-indanone

: 496062-47-6
ethyl {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc; copper(l) iodide / tetrahydrofuran / 0.25 h / Inert atmosphere; Reflux

1.2: 20 - 35 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 2068.65 Torr

3.1: Amano Lipase PS / water; acetone; aq. phosphate buffer / 20 °C / pH 7 / Enzymatic reaction

4.1: chloro-trimethyl-silane / Inert atmosphere

5.1: aluminum (III) chloride / dichloromethane / 0.17 h / 10 °C / Inert atmosphere

5.2: 2.5 h / 10 °C / Inert atmosphere

6.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; dichloromethane / 20 °C

With aluminum (III) chloride; copper(l) iodide; chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; triphenylphosphine; zinc; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; aq. phosphate buffer; ethanol; dichloromethane; water; acetone; 6.1: |Mitsunobu Displacement;

Reference yield:

: 73809-30-0
ethyl (5-methoxy-2,3-dihydro-1H-inden-1-ylidene)ethanoate

: 496062-47-6
ethyl {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 2068.65 Torr

2.1: Amano Lipase PS / water; acetone; aq. phosphate buffer / 20 °C / pH 7 / Enzymatic reaction

3.1: chloro-trimethyl-silane / Inert atmosphere

4.1: aluminum (III) chloride / dichloromethane / 0.17 h / 10 °C / Inert atmosphere

4.2: 2.5 h / 10 °C / Inert atmosphere

5.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; dichloromethane / 20 °C

With aluminum (III) chloride; chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; aq. phosphate buffer; ethanol; dichloromethane; water; acetone; 5.1: |Mitsunobu Displacement;