1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, (1S)-

Base Information

Chemical Name:1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, (1S)-
CAS No.:496062-48-7
Molecular Formula:C23H23NO4
Molecular Weight:377.44
Hs Code.:

Synonyms:

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Chemical Property of 1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, (1S)-

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Technology Process of 1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, (1S)-

There total 12 articles about 1H-Indene-1-acetic acid, 2,3-dihydro-5-[2-(4-methyl-2-phenyl-5-oxazolyl)ethoxy]-, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.6%

: 496062-47-6
ethyl {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetate

: 496062-48-7
{(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetic acid

Guidance literature:: With hydrogenchloride; LiOH; In tetrahydrofuran; ethanol; water;

Reference yield:

: 162713-88-4
ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)ethanoate

: 496062-48-7
{(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: Amano Lipase PS / water; acetone; aq. phosphate buffer / 20 °C / pH 7 / Enzymatic reaction

2.1: chloro-trimethyl-silane / Inert atmosphere

3.1: aluminum (III) chloride / dichloromethane / 0.17 h / 10 °C / Inert atmosphere

3.2: 2.5 h / 10 °C / Inert atmosphere

4.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; dichloromethane / 20 °C

5.1: lithium hydroxide; water / ethanol / 20 °C

With aluminum (III) chloride; chloro-trimethyl-silane; water; triphenylphosphine; lithium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; aq. phosphate buffer; ethanol; dichloromethane; water; acetone; 4.1: |Mitsunobu Displacement;

Reference yield:

: 5111-70-6
5-methoxy-1-indanone

: 496062-48-7
{(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc; copper(l) iodide / tetrahydrofuran / 0.25 h / Inert atmosphere; Reflux

1.2: 20 - 35 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 2068.65 Torr

3.1: Amano Lipase PS / water; acetone; aq. phosphate buffer / 20 °C / pH 7 / Enzymatic reaction

4.1: chloro-trimethyl-silane / Inert atmosphere

5.1: aluminum (III) chloride / dichloromethane / 0.17 h / 10 °C / Inert atmosphere

5.2: 2.5 h / 10 °C / Inert atmosphere

6.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; dichloromethane / 20 °C

7.1: lithium hydroxide; water / ethanol / 20 °C

With aluminum (III) chloride; copper(l) iodide; chloro-trimethyl-silane; palladium 10% on activated carbon; water; hydrogen; triphenylphosphine; lithium hydroxide; zinc; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; aq. phosphate buffer; ethanol; dichloromethane; water; acetone; 6.1: |Mitsunobu Displacement;