2-Propenoic acid, 2-azido-, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester

Base Information

Chemical Name:2-Propenoic acid, 2-azido-, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester
CAS No.:496068-17-8
Molecular Formula:C25H40N4O4S
Molecular Weight:492.683
Hs Code.:
Mol file:496068-17-8.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propenoic acid, 2-azido-, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester

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Technology Process of 2-Propenoic acid, 2-azido-, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester

There total 2 articles about 2-Propenoic acid, 2-azido-, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 496068-16-7
2,3-Dibromo-propionic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 496068-17-8
[(1R)-10-(N,N-dicyclohexylsulfamoyl)isobornyl] 2-azidoacrylate

Guidance literature:: 2,3-Dibromo-propionic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester; With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 60h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; N,N-dimethyl-formamide; for 0.333333h; Further stages.;
DOI:10.1039/b202321k

Reference yield:

: 96303-89-8
2-exo-acryloyloxy-N,N-dicyclohexylbornane-10-sulfonamide

: 496068-17-8
[(1R)-10-(N,N-dicyclohexylsulfamoyl)isobornyl] 2-azidoacrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / Br₂ / CH₂Cl₂ / 19 h / 20 °C

2.1: NaN₃ / dimethylformamide / 60 h / 20 °C

2.2: 73 percent / DBU / dimethylformamide; CH₂Cl₂ / 0.33 h

With sodium azide; bromine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b202321k