2H-Azirine-3-carboxylic acid, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester

Base Information

Chemical Name:2H-Azirine-3-carboxylic acid, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester
CAS No.:496068-18-9
Molecular Formula:C25H40N2O4S
Molecular Weight:464.67
Hs Code.:
Mol file:496068-18-9.mol

Synonyms:

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Chemical Property of 2H-Azirine-3-carboxylic acid, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester

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Technology Process of 2H-Azirine-3-carboxylic acid, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester

There total 3 articles about 2H-Azirine-3-carboxylic acid, (1S,2R,4R)-1-[[(dicyclohexylamino)sulfonyl]methyl]-7,7-dimethylbicyclo[ 2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 496068-17-8
[(1R)-10-(N,N-dicyclohexylsulfamoyl)isobornyl] 2-azidoacrylate

: 496068-18-9
[(1R)-10-(N,N-dicyclohexylsulfamoyl)isobornyl]-2H-azirine

Guidance literature:: In toluene; at 110 ℃; for 1.5h;
DOI:10.1039/b202321k

Reference yield:

: 96303-89-8
2-exo-acryloyloxy-N,N-dicyclohexylbornane-10-sulfonamide

: 496068-18-9
[(1R)-10-(N,N-dicyclohexylsulfamoyl)isobornyl]-2H-azirine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / Br₂ / CH₂Cl₂ / 19 h / 20 °C

2.1: NaN₃ / dimethylformamide / 60 h / 20 °C

2.2: 73 percent / DBU / dimethylformamide; CH₂Cl₂ / 0.33 h

3.1: 80 percent / toluene / 1.5 h / 110 °C

With sodium azide; bromine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b202321k

Reference yield:

: 496068-16-7
2,3-Dibromo-propionic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 496068-18-9
[(1R)-10-(N,N-dicyclohexylsulfamoyl)isobornyl]-2H-azirine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaN₃ / dimethylformamide / 60 h / 20 °C

1.2: 73 percent / DBU / dimethylformamide; CH₂Cl₂ / 0.33 h

2.1: 80 percent / toluene / 1.5 h / 110 °C

With sodium azide; In N,N-dimethyl-formamide; toluene;
DOI:10.1039/b202321k