2-Acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-Acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline
CAS No.:4965-16-6
Molecular Formula:C12H13NO
Molecular Weight:187.241
Hs Code.:
DSSTox Substance ID:DTXSID40451234
Nikkaji Number:J971.591F
Wikidata:Q82271155
Mol file:4965-16-6.mol

Synonyms:4965-16-6;2-ACETYL-1-METHYLENE-1,2,3,4-TETRAHYDROISOQUINOLINE;SCHEMBL7734490;1-(1-methylene-3,4-dihydroisoquinolin-2(1H)-yl)ethanone;DTXSID40451234;1-Methylene-2-acetyl-1,2,3,4-tetrahydroisoquinoline;1-(1-methylene-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

Suppliers and Price of 2-Acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

PSA：20.31000
LogP:1.99980
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:187.099714038
Heavy Atom Count:14
Complexity:259

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)N1CCC2=CC=CC=C2C1=C

Technology Process of 2-Acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about 2-Acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2412-58-0
1-methyl-3,4,dihydroisoquinoline

: 108-24-7
acetic anhydride

: 4965-16-6
1-(1-methylene-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: In pyridine; at 60 ℃; for 3h;
DOI:10.1055/s-0036-1588855

Reference yield:

: 64-04-0
phenethylamine

: 4965-16-6
1-(1-methylene-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 90 °C

2: PPA / 3.5 h / 130 - 200 °C

3: pyridine / 3 h / 60 °C

With pyridine;
DOI:10.1016/j.tetlet.2015.10.083

Reference yield:

: 877-95-2
methyl-N-(benzyl-methyl)-formamide

: 4965-16-6
1-(1-methylene-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: PPA / 3.5 h / 130 - 200 °C

2: pyridine / 3 h / 60 °C

With pyridine;
DOI:10.1016/j.tetlet.2015.10.083