3-Pyridinecarboxylic acid 3-pyridinylmethyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid 3-pyridinylmethyl ester
• CAS No.: 49673-77-0
• Molecular Formula: C12H10N2O2
• Molecular Weight: 214.224
• Mol file: 49673-77-0.mol

Synonyms:3-pyridinylmethyl nicotinate;pyridin-3-ylmethyl nicotinate;Nicotinsaeure-[3]pyridylmethylester;nicotinic acid 3-pyridinylmethyl ester;nicotinic acid-[3]pyridylmethyl ester;3-pyridinecarboxylic acid, 3-pyridinylmethyl ester;

Chemical Property of 3-Pyridinecarboxylic acid 3-pyridinylmethyl ester

Chemical Property:

• PSA: 52.08000
• LogP: 1.83360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid 3-pyridinylmethyl ester

There total 2 articles about 3-Pyridinecarboxylic acid 3-pyridinylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-pyridinecarboxaldehyde (500-22-1) → 3-hydroxymethylpyridin (100-55-0) + nicotinic acid (59-67-6) + 3-Pyridinecarboxylic acid 3-pyridinylmethyl ester (49673-77-0)

Guidance literature:

With aluminum (III) chloride; triethylamine; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1007/s00706-021-02785-9

Reference yield:

3-hydroxymethylpyridin (100-55-0) → 3-pyridinecarboxaldehyde (500-22-1) + 3-Pyridinecarboxylic acid 3-pyridinylmethyl ester (49673-77-0)

Guidance literature:

With C₄₄H₅₁IrN₉OsP; In toluene; at 100 ℃; for 18h; Overall yield = 36 %Spectr.; Schlenk technique;

DOI:10.1021/acs.organomet.8b00380

upstream raw materials:

3-hydroxymethylpyridin

3-pyridinecarboxaldehyde

Refernces

• 1、 Alabau, Roberto G.,Esteruelas, Miguel A.,Martínez, Antonio,Oliván, Montserrat,O?ate, Enrique. "Base-Free and Acceptorless Dehydrogenation of Alcohols Catalyzed by an Iridium Complex Stabilized by a N, N, N-Osmaligand". . p. 2732 - 2740. Retrieved 2018/09/10.