2-Oxazolidinone, 3-[(2S,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-2,4-bis(phenyl methoxy)butyl]-5,5-dimethyl-4-(phenylmethyl)-, (4S)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[(2S,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-2,4-bis(phenyl methoxy)butyl]-5,5-dimethyl-4-(phenylmethyl)-, (4S)-
CAS No.:496877-72-6
Molecular Formula:C36H47NO6Si
Molecular Weight:617.858
Hs Code.:

2-Oxazolidinone,
3-[(2S,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-2,4-bis(phenyl
methoxy)butyl]-5,5-dimethyl-4-(phenylmethyl)-, (4S)-

Synonyms:

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Chemical Property of 2-Oxazolidinone, 3-[(2S,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-2,4-bis(phenyl methoxy)butyl]-5,5-dimethyl-4-(phenylmethyl)-, (4S)-

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Technology Process of 2-Oxazolidinone, 3-[(2S,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-2,4-bis(phenyl methoxy)butyl]-5,5-dimethyl-4-(phenylmethyl)-, (4S)-

There total 3 articles about 2-Oxazolidinone, 3-[(2S,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-2,4-bis(phenyl methoxy)butyl]-5,5-dimethyl-4-(phenylmethyl)-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 496877-71-5
(2'S,3'R,4S)-4-benzyl-3-(2',4'-bis(benzyloxy)-3'-hydroxybutyryl)-5,5-dimethyloxazolidin-2-one

: 496877-72-6
(2'S,3'R,4S)-4-benzyl-3-(2',4'-bis(benzyloxy)-3'-(tert-butyldimethylsilanyloxy)butyryl)-5,5-dimethyloxazolidin-2-one

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1039/b415943h

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 496877-72-6
(2'S,3'R,4S)-4-benzyl-3-(2',4'-bis(benzyloxy)-3'-(tert-butyldimethylsilanyloxy)butyryl)-5,5-dimethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / Et₂BOTf; i-Pr₂NEt / CH₂Cl₂; hexane / -78 - 0 °C

2: 90 percent / imidazole; DMAP / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; dmap; N-ethyl-N,N-diisopropylamine; diethylboron trifluoromethanesulfonate; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b415943h

Reference yield:

: 496877-70-4
(S)-N-α-benzyloxyacetyl-4-benzyl-5,5-dimethyloxazolidin-2-one

: 496877-72-6
(2'S,3'R,4S)-4-benzyl-3-(2',4'-bis(benzyloxy)-3'-(tert-butyldimethylsilanyloxy)butyryl)-5,5-dimethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / Et₂BOTf; i-Pr₂NEt / CH₂Cl₂; hexane / -78 - 0 °C

2: 90 percent / imidazole; DMAP / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; dmap; N-ethyl-N,N-diisopropylamine; diethylboron trifluoromethanesulfonate; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b415943h