1,3-Dioxaspiro[4.5]dec-7-en-4-one, 2-(1,1-dimethylethyl)-8-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-[( 1E,3S)-3-hydroxy-2-methyl-1,5-hexadienyl]-9-methyl-, (2R,5S,6S,9R)-

Base Information

Chemical Name:1,3-Dioxaspiro[4.5]dec-7-en-4-one, 2-(1,1-dimethylethyl)-8-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-[( 1E,3S)-3-hydroxy-2-methyl-1,5-hexadienyl]-9-methyl-, (2R,5S,6S,9R)-
CAS No.:496917-94-3
Molecular Formula:C₃₇H₅₀O₅Si
Molecular Weight:602.886
Hs Code.:

1,3-Dioxaspiro[4.5]dec-7-en-4-one,
2-(1,1-dimethylethyl)-8-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-[(
1E,3S)-3-hydroxy-2-methyl-1,5-hexadienyl]-9-methyl-, (2R,5S,6S,9R)-

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Suppliers and Price of 1,3-Dioxaspiro[4.5]dec-7-en-4-one, 2-(1,1-dimethylethyl)-8-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-[( 1E,3S)-3-hydroxy-2-methyl-1,5-hexadienyl]-9-methyl-, (2R,5S,6S,9R)-

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Chemical Property of 1,3-Dioxaspiro[4.5]dec-7-en-4-one, 2-(1,1-dimethylethyl)-8-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-[( 1E,3S)-3-hydroxy-2-methyl-1,5-hexadienyl]-9-methyl-, (2R,5S,6S,9R)-

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Technology Process of 1,3-Dioxaspiro[4.5]dec-7-en-4-one, 2-(1,1-dimethylethyl)-8-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-[( 1E,3S)-3-hydroxy-2-methyl-1,5-hexadienyl]-9-methyl-, (2R,5S,6S,9R)-

There total 4 articles about 1,3-Dioxaspiro[4.5]dec-7-en-4-one, 2-(1,1-dimethylethyl)-8-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-[( 1E,3S)-3-hydroxy-2-methyl-1,5-hexadienyl]-9-methyl-, (2R,5S,6S,9R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146983-25-7
(E)-3-[(2R,5S,6S,9R)-2-tert-Butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-2-methyl-acrylic acid ethyl ester

: 496917-94-3
(2R,2R',3S,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(3-hydroxy-2-methyl-1,5-hexadiene)cyclohex-1-yl-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-one

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

3: toluene / 5 h / -78 °C

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In dichloromethane; toluene; 2: Swern oxidation;
DOI:10.3987/com-02-s(m)17

Reference yield:

: 497065-29-9
(2R,2R,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(2-methylpropen-1-ol)cyclohex-1-ene-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-ol

: 496917-94-3
(2R,2R',3S,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(3-hydroxy-2-methyl-1,5-hexadiene)cyclohex-1-yl-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-one

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

2: toluene / 5 h / -78 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; toluene; 1: Swern oxidation;
DOI:10.3987/com-02-s(m)17

Reference yield:

: 496917-89-6
(2R,2R',4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(2-methylpropen-1-ol)cyclohex-1-ene-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-one

: 496917-94-3
(2R,2R',3S,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(3-hydroxy-2-methyl-1,5-hexadiene)cyclohex-1-yl-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-one

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / SO₃*pyridine; Et₃N; DMSO / CH₂Cl₂ / 20 °C

2: toluene / 5 h / -78 °C

With pyridine-SO₃ complex; dimethyl sulfoxide; triethylamine; In dichloromethane; toluene; 1: Parikh-Doering reaction;
DOI:10.3987/com-02-s(m)17