497065-29-9

Upstream product

• 146983-18-8 ethyl 6-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-methyl-2(E),4(E),6(Z)-octatrienoate 
• 33935-64-7 methyl 2-(bromomethyl)-2-butenoate 
• 146983-22-4 methyl 4-<<(tert-butyldiphenylsilyl)oxy>methyl>-2(E),4(Z)-hexadienoate 
• 146983-20-2 methyl (2E)-2-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-butenoate 
• 146983-23-5 4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E),4(Z)-hexadienal 
• 146983-30-4 4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E),4(Z)-hexadienol 
• 129144-88-3 2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E)-butenal 
• 146983-21-3 2-<<(tert-butyldiphenylsilyl)oxy>methyl>-2(Z)-butenol 
• 28127-64-2 methyl (2E)-2-(hydroxymethyl)-2-butenoate 
• 98837-36-6 methyl 3-hydroxy-2-methylenebutyrate 
• 146983-25-7 (E)-3-[(2R,5S,6S,9R)-2-tert-Butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-2-methyl-acrylic acid ethyl ester 

Downstream Products

• 147058-91-1 methyl (1S,2S,5R)-4-<<(tert-butyldiphenylsilyl)oxy>methyl>-1-acetoxy-5-methyl-2-<2'-methyl-3'-<(tert-butyldimethylsilyl)oxy>-1'(E)-propen-1'yl>-3-cyclohexene-1-carboxylate 
• 146983-24-6 methyl (1S,2S,5R)-4-<<(tert-butyldiphenylsilyl)oxy>methyl>-1-hydroxy-5-methyl-2-<2'-methyl-3'-<(tert-butyldimethylsilyl)oxy>-1'(E)-propen-1'-yl>3-cyclohexene-1-carboxylate 
• 496917-82-9 C₇₇H₁₀₈O₈Si₃ 
• 496918-12-8 2-tert-butyl-6-[3-(tert-butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-2,6,12,14,16-pentamethyl-heptadeca-1,5,7,9,15-pentaenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one 
• 496917-79-4 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal 
• 496918-08-2 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal 
• 496918-23-1 (2R,5S,6S,9R)-2-tert-Butyl-6-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-5,6-dihydroxy-2-methyl-hex-1-enyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one 
• 496918-01-5 (2E,6E)-(S)-7-[(2R,5S,6S,9R)-2-tert-Butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-5-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-hepta-2,6-dienal 
• 496917-99-8 (E)-(S)-5-[(2R,5S,6S,9R)-2-tert-Butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pent-4-enal 
• 214198-28-4 (2R,5S,6S,9R)-2-tert-Butyl-6-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexa-1,5-dienyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one 
• 496917-94-3 (2R,2R',3S,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(3-hydroxy-2-methyl-1,5-hexadiene)cyclohex-1-yl-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-one 
• 496917-91-0 (E)-3-[(2R,5S,6S,9R)-2-tert-Butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-2-methyl-propenal 

Relevant academic research and scientific papers

Studies on the synthesis of kijanolide: Synthesis of an advanced seco-acid intermediate

A synthesis of an advanced seco acid intermediate (7) in a projected total synthesis of kijanolide is described. Key steps in the synthesis of 7 include the highly diastereoselective allylation reaction of 15, the Suzuki cross coupling of dienyl iodide (11) and vinylboronic acid (12), and the IMDA reaction of 9. Elaboration of the spirotetronic acid unit of 7 was accomplished by a Dieckmann cyclization of the α-acetoxy ester intermediate derived from the IMDA cycloadduct (39).

A Highly Diastereo- and Enantioselective Synthesis of the Top Half of Kijanolide

A highly diastereo- and enantioselective synthesis of spirotetronate 4 corresponding to the top half of kijanolide is reported.This synthesis features the novel exo-selective Diels-Alder reaction of triene 6 and the chiral, nonracemic dienophiles (R)-7 an