Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)tetra hydro-2,4,6-trioxo-1,3,5-triazin-1(2H)-yl]-1-phenylethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)tetra hydro-2,4,6-trioxo-1,3,5-triazin-1(2H)-yl]-1-phenylethyl]-, 1,1-dimethylethyl ester
CAS No.:496929-88-5
Molecular Formula:C₃₀H₂₉F₃N₄O₆
Molecular Weight:598.579
Hs Code.:

Carbamic acid,
[(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)tetra
hydro-2,4,6-trioxo-1,3,5-triazin-1(2H)-yl]-1-phenylethyl]-,
1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)tetra hydro-2,4,6-trioxo-1,3,5-triazin-1(2H)-yl]-1-phenylethyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)tetra hydro-2,4,6-trioxo-1,3,5-triazin-1(2H)-yl]-1-phenylethyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)tetra hydro-2,4,6-trioxo-1,3,5-triazin-1(2H)-yl]-1-phenylethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1022158-75-3
2-fluoro-3-methoxyphenyl isocyanate

: 496929-88-5
{2-[3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h

2: CH₂Cl₂ / 12 h / 20 °C

3: PPh₃; di-t-butyl azodicarboxylate / tetrahydrofuran / 5 h

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.038

Reference yield:

: 496929-86-3
N-(2-fluoro-3-methoxyphenyl)-N'-(2,6-difluorobenzyl)urea

: 496929-88-5
{2-[3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 12 h / 20 °C

2: PPh₃; di-t-butyl azodicarboxylate / tetrahydrofuran / 5 h

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.038

Reference yield:

: 69385-30-4
2,6-difluorobenzylamine

: 496929-88-5
{2-[3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h

2: CH₂Cl₂ / 12 h / 20 °C

3: PPh₃; di-t-butyl azodicarboxylate / tetrahydrofuran / 5 h

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.038