69385-30-4

Basic information

• Product Name: 2,6-Difluorobenzylamine
• Synonyms: RARECHEM AL BW 0011;TIMTEC-BB SBB006568;2,6-DIFLUOROBENZYLAMINE;(2,6-Difluorophenyl)methanamine;Benzenemethanamine, 2,6-difluoro-;2,6-Difluorobenzylamine,97%;2,6-Difluorobenzylamine 97%;2,6-Difluorobenzylam
• CAS NO: 69385-30-4
• Molecular Formula: C₇H₇F₂N
• Molecular Weight: 143.13
• EINECS: 273-983-9
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Amine;Miscellaneous;Fluorobenzylamine Series;Amines;C7;Nitrogen Compounds;Fluorine series
• Mol File: 69385-30-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 174-177°C
• Flash Point: 150 °F
• Appearance: clear colorless to yellow liquid
• Density: 1.197 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.32mmHg at 25°C
• Refractive Index: n20/D 1.493(lit.)
• Storage Temp.: Store below +30°C.
• PKA: 8.21±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 2716771
• CAS DataBase Reference: 2,6-Difluorobenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorobenzylamine(69385-30-4)
• EPA Substance Registry System: 2,6-Difluorobenzylamine(69385-30-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45-25
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 69385-30-4(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

2,6-Difluorobenzylamine has been used in the synthesis of:(Z)-N1-(2,6-difluorobenzyl)-N2-(2-amino-1,2-dicyanovinyl)formamidine2,6-difluorobenzyl-guanidine hydrochloride

InChI:InChI=1/C7H7F2N/c8-6-2-1-3-7(9)5(6)4-10/h1-3H,4,10H2/p+1

Upstream product

• 1897-52-5 2,6 difluorobenzonitrile 
• 697-73-4 2,6-difluorobenzyl chloride 
• 19064-16-5 2,6-difluoro-benzaldehyde oxime 

Downstream Products

• 17751-24-5 N-(2,6-difluorobenzyl) urea 
• 392626-93-6 tert-Butyl 4-[(1-{[(2,6-difluorobenzyl)amino]carbonyl}-4-piperidinyl)amino]phenethylcarbamate 
• 330669-96-0 (R)-1-(2,6-difluoro-benzylamino)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol 
• 330669-79-9 (R)-1-(4-benzo[b]thiophen-3-yl-phenoxy)-3-(2,6-difluoro-benzylamino)-propan-2-ol 
• 480458-44-4 C₂₇H₂₃F₃N₆ 
• 1082208-85-2 C₈H₆F₅NO₂S 
• 1082208-82-9 C₈H₉F₂NO₂S 
• 1133758-56-1 5-amino-1-(2,6-difluorobenzyl)-1H-imidazole-4-carbonitrile 
• 1100642-15-6 2-chloro-N-(2,6-difluorobenzyl)-9H-purin-6-amine 
• 1345857-41-1 C₁₄H₁₃F₂NO 
• 1346265-43-7 1-(2,6-difluorobenzylamino)-3-(1,2,3,4-tetrahydro-9H-carbazol-9-yl)-2-propanol 

Relevant articles and documents

Gabriel reaction in the synthesis of 2,6-difluorobenzyl amine

2,6-Difluorobenzyl amine was obtained by Gabriel reaction with a good yield. Intermediate N-(2,6-difluorobenzyl) phthalimide was obtained in the presence of phase transfer catalysts.

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed

Novel benzylideneaminoguanidines

This disclosure describes novel substituted benzylideneaminoguanidines useful as anti-hypertensive agents and as diuretics.