1-Piperazinecarboxylic acid, 4-[4-[4-[(3-ethyl-4-methylphenyl)amino]-3,6-dihydro-2,6-dioxo-1(2H)-pyr imidinyl]butyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[4-[4-[(3-ethyl-4-methylphenyl)amino]-3,6-dihydro-2,6-dioxo-1(2H)-pyr imidinyl]butyl]-, 1,1-dimethylethyl ester
CAS No.:496943-52-3
Molecular Formula:C26H39N5O4
Molecular Weight:485.627
Hs Code.:
Mol file:496943-52-3.mol

1-Piperazinecarboxylic acid,
4-[4-[4-[(3-ethyl-4-methylphenyl)amino]-3,6-dihydro-2,6-dioxo-1(2H)-pyr
imidinyl]butyl]-, 1,1-dimethylethyl ester

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[4-[4-[(3-ethyl-4-methylphenyl)amino]-3,6-dihydro-2,6-dioxo-1(2H)-pyr imidinyl]butyl]-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperazinecarboxylic acid, 4-[4-[4-[(3-ethyl-4-methylphenyl)amino]-3,6-dihydro-2,6-dioxo-1(2H)-pyr imidinyl]butyl]-, 1,1-dimethylethyl ester

There total 6 articles about 1-Piperazinecarboxylic acid, 4-[4-[4-[(3-ethyl-4-methylphenyl)amino]-3,6-dihydro-2,6-dioxo-1(2H)-pyr imidinyl]butyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 308833-37-6
3-(4-Iodobutyl)-6-(3-ethyl-4-methylanilino)uracil

: 496943-52-3
3-{4-[4-(tert-butoxycarbonyl)piperazino-1-yl]butyl}-6-(3-ethyl-4-methylanilino)uracil

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm020591z

Reference yield: 62.0%

: 496943-52-3
3-{4-[4-(tert-butoxycarbonyl)piperazino-1-yl]butyl}-6-(3-ethyl-4-methylanilino)uracil

Guidance literature:

Reference yield:

: 98385-96-7
N-(4-Methoxybutyl)harnstoff

: 496943-52-3
3-{4-[4-(tert-butoxycarbonyl)piperazino-1-yl]butyl}-6-(3-ethyl-4-methylanilino)uracil

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / NaOEt / 6 h / Heating

2: 70 percent / benzyltriethylammonium chloride; POCl₃ / 3 h / 50 °C

3: 72 percent / 0.5 h / 150 °C

4: 84 percent / Me₃SiI / CHCl₃ / Heating

5: 62 percent / K₂CO₃ / dimethylformamide / 20 °C

With trimethylsilyl iodide; N-benzyl-N,N,N-triethylammonium chloride; sodium ethanolate; potassium carbonate; trichlorophosphate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm020591z