4-Hexenoic acid, 2-amino-3-(dimethylphenylsilyl)-, methyl ester, (2R,3R,4E)-

Base Information

Chemical Name:4-Hexenoic acid, 2-amino-3-(dimethylphenylsilyl)-, methyl ester, (2R,3R,4E)-
CAS No.:497065-79-9
Molecular Formula:C15H23NO2Si
Molecular Weight:277.439
Hs Code.:

Synonyms:

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Chemical Property of 4-Hexenoic acid, 2-amino-3-(dimethylphenylsilyl)-, methyl ester, (2R,3R,4E)-

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Technology Process of 4-Hexenoic acid, 2-amino-3-(dimethylphenylsilyl)-, methyl ester, (2R,3R,4E)-

There total 2 articles about 4-Hexenoic acid, 2-amino-3-(dimethylphenylsilyl)-, methyl ester, (2R,3R,4E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136824-22-1
methyl (2R,3R)-α-azido-β-(dimethylphenylsilyl)-(E)-hex-4-enoate

: 497065-79-9
(E)-(2R,3R)-2-Amino-3-(dimethyl-phenyl-silanyl)-hex-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 0 deg C to r.t.

2: 5percent HCl

With hydrogenchloride; In diethyl ether;
DOI:10.1021/jo00054a002

Reference yield:

: C₃₃H₃₆NO₂PSi

: 497065-79-9
(E)-(2R,3R)-2-Amino-3-(dimethyl-phenyl-silanyl)-hex-4-enoic acid methyl ester

Guidance literature:: With hydrogenchloride;
DOI:10.1021/jo00054a002

Reference yield: 75.0%

: 3132-99-8
m-bromobenzoic aldehyde

: 497065-79-9
(E)-(2R,3R)-2-Amino-3-(dimethyl-phenyl-silanyl)-hex-4-enoic acid methyl ester

: 407-25-0
trifluoroacetic anhydride

: 916914-98-2
methyl (2S,5R,6R)-6-(3-bromophenyl)-1-(2,2,2-trifluoroacetyl)-1,2,5,6-tetrahydro-5-methylpyridine-2-carboxylate

Guidance literature:: m-bromobenzoic aldehyde; (E)-(2R,3R)-2-Amino-3-(dimethyl-phenyl-silanyl)-hex-4-enoic acid methyl ester; With magnesium sulfate; In dichloromethane; at 20 ℃; for 0.5h;

With titanium tetrachloride; In dichloromethane; at -78 - 20 ℃;

trifluoroacetic anhydride; With pyridine; In dichloromethane; at -78 ℃; for 2h; Further stages.;
DOI:10.1021/ol070321g