2-Pentanol, 4-iodo-, 4-methylbenzenesulfonate

Base Information

• Chemical Name: 2-Pentanol, 4-iodo-, 4-methylbenzenesulfonate
• CAS No.: 497068-87-8
• Molecular Formula: C12H17IO3S
• Molecular Weight: 368.236
• Mol file: 497068-87-8.mol

Synonyms:

Chemical Property of 2-Pentanol, 4-iodo-, 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pentanol, 4-iodo-, 4-methylbenzenesulfonate

There total 1 articles about 2-Pentanol, 4-iodo-, 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pentane-1,3-diol (1825-14-5,3950-21-8,36402-52-5,42075-32-1,72345-23-4,625-69-4) → 3-iodo-1-methylbutyl p-toluenesulfonate (497068-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NEt₃; mesyl chloride / CH₂Cl₂ / 14 h / 0 - 20 °C

1.2: 28 percent / MgI₂ / diethyl ether / 0.75 h / 20 °C

2.1: 76 percent / Et₃N; Me₃N*HCl / CH₂Cl₂

With trimethylamine hydrochloride; methanesulfonyl chloride; triethylamine; In dichloromethane;

DOI:10.1002/1099-0690(200208)2002:16<2742::AID-EJOC2742>3.0.CO;2-R

Reference yield: 65.0%

3-iodo-1-methylbutyl p-toluenesulfonate (497068-87-8) → 4-(p-tolyl)-2-pentanol (61235-21-0)

Guidance literature:

3-iodo-1-methylbutyl p-toluenesulfonate; With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile); In benzene; at 80 ℃; for 7.5h;

With methyllithium; In benzene; at 20 ℃; for 14h; Further stages.;

DOI:10.1002/1099-0690(200208)2002:16<2742::AID-EJOC2742>3.0.CO;2-R

Reference yield:

3-iodo-1-methylbutyl p-toluenesulfonate (497068-87-8) → 2-amino-4-(p-tolyl)pentane

Guidance literature:

Multi-step reaction with 4 steps

1.1: Bu₃SnH / AIBN / benzene / 7.5 h / 80 °C

1.2: 65 percent / MeLi / benzene / 14 h / 20 °C

2.1: 99 percent / Et₃N / CH₂Cl₂ / 14 h / 20 °C

3.1: 89 percent / NaN₃ / dimethylsulfoxide / 74 h / 70 °C

4.1: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

4.2: 99 percent / diethyl ether / 0.5 h / Heating

With lithium aluminium tetrahydride; sodium azide; tri-n-butyl-tin hydride; triethylamine; 2,2'-azobis(isobutyronitrile); In diethyl ether; dichloromethane; dimethyl sulfoxide; benzene;

DOI:10.1002/1099-0690(200208)2002:16<2742::AID-EJOC2742>3.0.CO;2-R

upstream raw materials:

pentane-1,3-diol

Downstream raw materials:

4-(p-tolyl)-2-pentanol