2-Chloro-n-(3-nitrophenyl)-3-phenylpropanamide

Base Information

Chemical Name:2-Chloro-n-(3-nitrophenyl)-3-phenylpropanamide
CAS No.:6632-27-5
Molecular Formula:C15H13 Cl N2 O3
Molecular Weight:304.7283
Hs Code.:
NSC Number:57779
DSSTox Substance ID:DTXSID10288837

Synonyms:2-chloro-n-(3-nitrophenyl)-3-phenylpropanamide;NSC57779;DTXSID10288837;NSC-57779

Suppliers and Price of 2-Chloro-n-(3-nitrophenyl)-3-phenylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2-Chloro-n-(3-nitrophenyl)-3-phenylpropanamide

Chemical Property:

Vapor Pressure:1.43E-10mmHg at 25°C
Boiling Point:511.3°Cat760mmHg
Flash Point:263°C
Density:1.364g/cm³
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:304.0614700
Heavy Atom Count:21
Complexity:366

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(C(=O)NC2=CC(=CC=C2)[N+](=O)[O-])Cl

Technology Process of 2-Chloro-n-(3-nitrophenyl)-3-phenylpropanamide

There total 4 articles about 2-Chloro-n-(3-nitrophenyl)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81136-10-9,120710-94-3,120710-95-4,54468-36-9
2-chloro-3-phenylpropanoic acid chloride

: 99-09-2
3-nitro-aniline

: 6632-27-5
2-chloro-N-(3-nitrophenyl)-3-phenylpropanamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tet.2017.01.045

Reference yield:

: 4530-18-1
2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

: 6632-27-5
2-chloro-N-(3-nitrophenyl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C

2: hydrogenchloride; sodium nitrite / water / 24 h / 20 °C

3: thionyl chloride; N,N-dimethyl-formamide / 1 h / 70 °C

4: N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide; sodium nitrite; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2017.01.045

Reference yield:

: 27172-85-6
phenylalanine methyl ester hydrochloride

: 6632-27-5
2-chloro-N-(3-nitrophenyl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite / water / 24 h / 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / 1 h / 70 °C

3: N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2017.01.045