(+-)-cis-4-tert-Butyl-2-(4-phenylpiperidino)cyclohexanol hydrochloride

Base Information

• Chemical Name: (+-)-cis-4-tert-Butyl-2-(4-phenylpiperidino)cyclohexanol hydrochloride
• CAS No.: 120447-54-3
• Molecular Formula: C₂₁H₃₃NO*ClH
• Molecular Weight: 351.96
• DSSTox Substance ID: DTXSID70152868
• Mol file: 120447-54-3.mol

Synonyms:(+-)-cis-4-tert-Butyl-2-(4-phenylpiperidino)cyclohexanol hydrochloride;Cyclohexanol, 4-(1,1-dimethylethyl)-2-(4-phenyl-1-piperidinyl)-, hydrochloride, (1-alpha,2-beta,4-alpha)-(+-)-;120447-54-3;DTXSID70152868;LS-57151

Chemical Property of (+-)-cis-4-tert-Butyl-2-(4-phenylpiperidino)cyclohexanol hydrochloride

Chemical Property:

• Vapor Pressure: 3.61E-08mmHg at 25°C
• Boiling Point: 430.3°C at 760 mmHg
• Flash Point: 30.4°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 351.2328924
• Heavy Atom Count: 24
• Complexity: 361

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1CCC(C(C1)N2CCC(CC2)C3=CC=CC=C3)O.Cl
• Isomeric SMILES: CC(C)(C)[C@@H]1CC[C@@H]([C@H](C1)N2CCC(CC2)C3=CC=CC=C3)O.Cl

Technology Process of (+-)-cis-4-tert-Butyl-2-(4-phenylpiperidino)cyclohexanol hydrochloride

There total 1 articles about (+-)-cis-4-tert-Butyl-2-(4-phenylpiperidino)cyclohexanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-phenylpiperidine (771-99-3) + cis-1,2-Epoxy-4-tert-Butylcyclohexane (14753-39-0) → (+/-)-cis-4-tert-butyl-trans-2-(4-phenylpiperidino)cyclohexanol hydrochloride (120447-54-3)

Guidance literature:

In ethanol; Heating;

DOI:10.1021/jm00126a013

upstream raw materials:

4-phenylpiperidine

cis-1,2-Epoxy-4-tert-Butylcyclohexane