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771-99-3

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771-99-3 Usage

Chemical Properties

off-white to light brown crystalline powder and/or

Uses

4-Phenylpiperidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Definition

4-Phenylpiperidine is a benzene ring bound to a piperidine ring. It is the base structure for a variety of opioids, such as pethidine (meperidine), ketobemidone, alvimopan, loperamide, and diphenoxylate.

Check Digit Verification of cas no

The CAS Registry Mumber 771-99-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,7 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 771-99:
(5*7)+(4*7)+(3*1)+(2*9)+(1*9)=93
93 % 10 = 3
So 771-99-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2/p+1

771-99-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H66389)  4-Phenylpiperidine, 96%   

  • 771-99-3

  • 1g

  • 331.0CNY

  • Detail
  • Alfa Aesar

  • (H66389)  4-Phenylpiperidine, 96%   

  • 771-99-3

  • 5g

  • 1274.0CNY

  • Detail
  • Aldrich

  • (639869)  4-Phenylpiperidine  97%

  • 771-99-3

  • 639869-1G

  • 463.32CNY

  • Detail
  • Aldrich

  • (639869)  4-Phenylpiperidine  97%

  • 771-99-3

  • 639869-5G

  • 1,210.95CNY

  • Detail

771-99-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Phenylpiperidine

1.2 Other means of identification

Product number -
Other names Piperidine,4-phenyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:771-99-3 SDS

771-99-3Relevant articles and documents

Synthetic method of 4 -phenyl piperidine hydrochloride

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Paragraph 0011; 0052; 0055; 0057; 0060; 0062; 0065; ..., (2021/11/06)

The invention discloses a synthesis method of 4 -phenylpiperidine hydrochloride, and the route is as shown in the specification. The method has the advantages of cheap and easily available raw materials, simple operation and post-treatment, high yield, high product purity and the like, and is suitable for industrial production.

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

Fyfe, Tim J.,Kellam, Barrie,Sykes, David A.,Capuano, Ben,Scammells, Peter J.,Lane, J. Robert,Charlton, Steven J.,Mistry, Shailesh N.

, p. 9488 - 9520 (2019/11/11)

Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side effects (EPSs) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D2 receptor (D2R) antagonists, with contrasting kinetic profiles. Haloperidol displays fast association/slow dissociation at the D2R, whereas clozapine exhibits relatively slow association/fast dissociation. Recently, we have provided evidence that slow dissociation from the D2R predicts hyperprolactinemia, whereas fast association predicts EPS. Unfortunately, clozapine can cause severe side effects independent of its D2R action. Our results suggest an optimal kinetic profile for D2R antagonist APDs that avoids EPS. To begin exploring this hypothesis, we conducted a structure-kinetic relationship study of haloperidol and revealed that subtle structural modifications dramatically change binding kinetic rate constants, affording compounds with a clozapine-like kinetic profile. Thus, optimization of these kinetic parameters may allow development of novel APDs based on the haloperidol scaffold with improved side-effect profiles.

Modulators of protease activated receptors

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Page/Page column 33; 34, (2018/02/20)

The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.

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