1-Benzazocine-5-carboxamide, 8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4- [[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]-

Base Information

Chemical Name:1-Benzazocine-5-carboxamide, 8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4- [[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]-
CAS No.:497223-22-0
Molecular Formula:C₄₁H₅₂N₄O₅S
Molecular Weight:712.954
Hs Code.:

1-Benzazocine-5-carboxamide,
8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4-
[[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]-

Synonyms:

Suppliers and Price of 1-Benzazocine-5-carboxamide, 8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4- [[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CenicrivirocSulfone
10mg
$ 2420.00

Total 5 raw suppliers

Chemical Property of 1-Benzazocine-5-carboxamide, 8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4- [[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]-

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

CenicrivirocSulfone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Cenicriviroc Sulfone is a derivative of Cenicriviroc (C256550) which is an experimental drug candidate for the treatment of HIV infection. It is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell.

Technology Process of 1-Benzazocine-5-carboxamide, 8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4- [[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]-

There total 9 articles about 1-Benzazocine-5-carboxamide, 8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4- [[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 8-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[[1-propyl-1H-imidazol-5-yl ]methyl]sufanyl]phenyl]-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide

: 8-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[[1-propylimidazol-5-yl]methyl]sulfinyl]phenyl]-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide

: 497223-22-0
8-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[[1-propyl-1H-imidazol-5-yl]methyl]sulfonyl]phenyl]-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 0 ℃; for 0.5h;

Reference yield:

: 675-20-7
piperidin-2-one

: 497223-22-0
8-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[[1-propyl-1H-imidazol-5-yl]methyl]sulfonyl]phenyl]-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide; tetrabutylammomium bromide / toluene / 2.5 h / 115 °C / Dean-Stark

2.1: sodium carbonate; methanesulfonic acid / water; ethyl acetate; dimethyl sulfoxide / 1 h / 50 °C

2.2: 6 h / 135 °C

3.1: potassium carbonate / water; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4.1: carbonic acid dimethyl ester; sodium methylate / methanol / 3 h / 50 °C / Inert atmosphere

5.1: potassium carbonate / ethanol; water; toluene / 3 h / 105 °C

5.2: 3 h / 100 °C / Inert atmosphere

6.1: sodium hydroxide / water / 84 h / 90 °C

7.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / Inert atmosphere

8.1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

8.2: 0.5 h / Inert atmosphere

8.3: 1.5 h / Inert atmosphere

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / -78 - 0 °C

With thionyl chloride; methanesulfonic acid; tetrabutylammomium bromide; sodium methylate; sodium carbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; carbonic acid dimethyl ester; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 497224-01-8
1-isobutyl-2-piperidone

: 497223-22-0
8-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[[1-propyl-1H-imidazol-5-yl]methyl]sulfonyl]phenyl]-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate; methanesulfonic acid / water; ethyl acetate; dimethyl sulfoxide / 1 h / 50 °C

1.2: 6 h / 135 °C

2.1: potassium carbonate / water; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3.1: carbonic acid dimethyl ester; sodium methylate / methanol / 3 h / 50 °C / Inert atmosphere

4.1: potassium carbonate / ethanol; water; toluene / 3 h / 105 °C

4.2: 3 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide / water / 84 h / 90 °C

6.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / Inert atmosphere

7.1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

7.2: 0.5 h / Inert atmosphere

7.3: 1.5 h / Inert atmosphere

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / -78 - 0 °C

With thionyl chloride; methanesulfonic acid; sodium methylate; sodium carbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; carbonic acid dimethyl ester; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;