Carbamic acid, [(1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentyl]-, (1R)-2-methyl-1-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]propyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentyl]-, (1R)-2-methyl-1-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]propyl ester
CAS No.:497946-89-1
Molecular Formula:C₄₀H₄₁N₄O₄P
Molecular Weight:672.764
Hs Code.:

Carbamic acid,
[(1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentyl]-,
(1R)-2-methyl-1-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]propyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentyl]-, (1R)-2-methyl-1-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]propyl ester

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Technology Process of Carbamic acid, [(1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentyl]-, (1R)-2-methyl-1-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]propyl ester

There total 4 articles about Carbamic acid, [(1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentyl]-, (1R)-2-methyl-1-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863651-39-2
(R)-3-Methyl-1-(5-phenyl-[1,3,4]oxadiazol-2-yl)-butan-2-ol

: 497946-89-1
{(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (R)-2-methyl-1-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 85 °C

2: aq. LiOH / tetrahydrofuran

3: DMAP; EDC / CH₂Cl₂

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.05.062

Reference yield:

: (S)-2-[(R)-2-Methyl-1-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-propoxycarbonylamino]-hexanoic acid methyl ester

: 497946-89-1
{(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (R)-2-methyl-1-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. LiOH / tetrahydrofuran

2: DMAP; EDC / CH₂Cl₂

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.062

Reference yield:

: 4046-03-1
2-methyl-5-phenyl-[1,3,4]oxadiazole

: 497946-89-1
{(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (R)-2-methyl-1-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiTMP / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: toluene / 85 °C

3.1: aq. LiOH / tetrahydrofuran

4.1: DMAP; EDC / CH₂Cl₂

With dmap; lithium hydroxide; 2,2,6,6-tetramethylpiperidinyl-lithium; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.05.062