Benzoyl hydrazine

Base Information

• Chemical Name: Benzoyl hydrazine
• CAS No.: 613-94-5
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• Hs Code.: 29280090
• European Community (EC) Number: 210-363-9
• NSC Number: 644
• UNII: LLW11ZWZ20
• DSSTox Substance ID: DTXSID6020149
• Nikkaji Number: J30.698C
• Wikidata: Q27117861
• Metabolomics Workbench ID: 55874
• ChEMBL ID: CHEMBL125369
• Mol file: 613-94-5.mol

Synonyms:Benzenecarboxylicacid hydrazide;Benzhydrazide;Benzohydrazide;Benzoic hydrazide;Benzoylhydrazine;Hydrazine, benzoyl-;INHd 14;N-Benzoylhydrazine;NSC 644;

Chemical Property of Benzoyl hydrazine

Chemical Property:

• Appearance/Colour: White to beige needle-like crystals or powder
• Vapor Pressure: 0.000315mmHg at 25°C
• Melting Point: 112-114 °C(lit.)
• Refractive Index: 1.577
• Boiling Point: 307.4ºC at 760 mmHg
• PKA: pK1: 3.03(+2);pK2: 12.45(+1) (25°C)
• Flash Point: 139.7ºC
• PSA: 55.12000
• Density: 1.164 g/cm³
• LogP: 1.38130
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 119

Purity/Quality:

99% ^*data from raw suppliers

BenzoylHydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydrazides
• Canonical SMILES: C1=CC=C(C=C1)C(=O)NN
• Uses: Benzoyl Hydrazine is an acyl hydrazide as potent antioxidant.

Technology Process of Benzoyl hydrazine

There total 115 articles about Benzoyl hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzoyl chloride (98-88-4) → benzoic acid hydrazide (613-94-5)

Guidance literature:

With hydrazine; In dichloromethane; water; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2010.08.002

Reference yield: 98.0%

5-phenyl-3H-[1,3,4]oxadiazol-2-one (1199-02-6) + 1,2-diamino-benzene (95-54-5) → 1,3-dihydro-2H-benzimidazol-2-one (615-16-7) + benzoic acid hydrazide (613-94-5)

Guidance literature:

In various solvent(s); at 150 ℃; for 5h;

Reference yield: 95.0%

1-benzoyl-1H-benzotriazole (4231-62-3) → benzoic acid hydrazide (613-94-5)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; at 20 ℃; for 0.25h;

upstream raw materials:

5-phenyl-3H-[1,3,4]oxadiazol-2-one

aniline

benzoyl-trityl-diazene

cyclohexane

Downstream raw materials:

N-benzoyl-N'-[4]pyridylmethylene-N-thioisonicotinoyl-hydrazine

2-pyridyl carboxaldehyde benzoylhydrazone (E-isomer)

[N'-(furfurylidene)]benzhydrazide

benzoic acid-(1-methyl-[4]piperidylidenehydrazide)

Refernces

• 1、 Dzhumadullaeva,Altynbekova. "A mechanism for the hydrazinolysis of benzoic acid in the presence of ion-exchange catalyst". . p. 1943 - 1945. Retrieved 2013.
• 2、 Arjunan,Rani,Mythili,Mohan. "Synthesis, FTIR, FT-Raman, UV-visible, ab initio and DFT studies on benzohydrazide". . p. 486 - 496. Retrieved 2011.
• 3、 Jacobson, Alan, R.,Makris, Angelo N.,Sayre, Lawrence M.. "Monoacylation of Symmetrical Diamines". . p. 2592 - 2594. Retrieved 1987.
• 4、 Abu-Eid, Maher A.,Mahmoud, Foad M.,Al-Nuri, Mohammed A.,Abu Zuhri, Ali Z.. "Kinetic Studies of the Hydrolysis of Furfurylidene Benzoylhydrazone". . p. 323 - 328. Retrieved 1989.
• 5、 Jha, Ajit Kumar,Kumari, Rajkiran,Easwar, Srinivasan. "Synthesis of 2,2-Disubstituted Dihydro-1,4-benzothiazines from Morita-Baylis-Hillman Ketones by an Oxidative Cyclization". . p. 5760 - 5772. Retrieved 2022/05/07.
• 6、 Bai, Hangyu,Jiang, Weiqi,Li, Qi,Li, Tian,Ma, Shichuang,Shi, Baojun,Wu, Wenjun. "Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles". . p. 11572 - 11581. Retrieved 2021/10/12.