Refernces
10.1016/j.ica.2010.05.009
The study focuses on the synthesis and characterization of five new Ni(II) complexes with aroyl hydrazone ligands derived from 2,6-diacetyl pyridine monooxime. The complexes were found to have a distorted octahedral N4O2 coordination environment around the Ni(II) ion, with the ligands coordinating through the pyridine nitrogen, imino-hydrazone nitrogen, and the deprotonated oxygen of the hydrazone moiety. The uncoordinated iminooxime groups and the orthogonal orientation of the CH3–C@N–OH groups relative to the adjacent pyridine rings were observed. The ligands and their corresponding Ni(II) complexes exhibited luminescence, with the complexes showing a lower quantum yield compared to the free ligands. The study also includes the X-ray crystal structure of the Ni(II) salicyloylhydrazone complex, which revealed details about the molecular structure and hydrogen bonding interactions in the crystal lattice. The research provides insights into the coordination chemistry of aroyl hydrazone ligands and their potential applications in areas such as pharmaceuticals and materials science.
10.1016/j.bmc.2021.116209
This research aimed to evaluate the potential of iodinated hydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents, addressing the increasing resistance of bacterial and fungal pathogens to existing treatments. The study synthesized and screened twenty-two iodinated hydrazide-hydrazones and ten 1,2-diacylhydrazines, along with their three reduced analogues, for their antibacterial, antifungal, and cytotoxic properties. The compounds were tested against eight bacterial and eight fungal strains, and their cytotoxicity was assessed on HepG2 and HK-2 cell lines. The study found that certain derivatives, particularly those containing the 3,5-diiodosalicylidene scaffold, exhibited potent antibacterial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), with low minimum inhibitory concentrations (MIC) values. Some compounds also showed antifungal activity and variable degrees of cytotoxicity, with normal human cells exhibiting lower sensitivity. The research concluded that these compounds, especially those with electron-withdrawing groups like F, Cl, CF3, and NO2, have potential as antimicrobial and cytotoxic agents. The chemicals used in the process included various substituted benzohydrazides, 2-/4-hydroxy-3,5-diiodobenzaldehydes, 3,5-diiodosalicylic acid, and their derivatives, as well as reagents for biological assays and cytotoxicity tests.
10.1016/j.ica.2009.07.008
The research investigates the interaction of a novel hesperetin Schiff base ligand (H4L) and its copper(II) and zinc(II) complexes with DNA, as well as their antioxidative properties. The study aims to explore the binding mechanisms of these compounds to DNA and their potential as antitumor drugs and antioxidants. Key chemicals used include hesperetin, benzoyl hydrazine, copper(II) acetate, zinc(II) acetate, and calf thymus DNA. The researchers synthesized the ligand and its complexes and characterized them using various spectroscopic techniques. They found that all compounds bind to DNA through an intercalative mode, with the metal complexes showing stronger binding affinity than the free ligand. Additionally, the complexes exhibited higher antioxidative activity in scavenging superoxide radicals and hydroxyl radicals compared to the ligand. The findings suggest that these metal complexes could be valuable candidates for developing new antitumor drugs and antioxidants.
10.1246/bcsj.79.644
This research aims to synthesize and characterize a series of 1,3,4-oxadiazole–1,2,3-triazole hybrid derivatives as potential blue electroluminescent materials. The study introduces 1,2,3-triazole into the skeletal structure of 1,3,4-oxadiazole to create these hybrid compounds. Key chemicals used in the synthesis include POCl3, DMF, ethyl 4-hydrazinylbenzoate, benzoyl chloride, and various substituted benzohydrazides. The UV–vis absorption maxima of these derivatives are in the range of 340–360 nm, and their photoluminescence maxima are between 406–480 nm. The fluorescence quantum yields range from 0.65 to 0.76. Cyclic voltammetry measurements reveal unclearly reversible reduction processes, with HOMO values and bandgap energies indicating their potential as electron-transporting materials. The study concludes that the 1,3,4-oxadiazole–1,2,3-triazole derivatives are highly potential efficient blue electroluminescent materials, with the triazole moiety playing a significant role in controlling fundamental photolytic processes.
10.1080/10426500802625594
The research aimed to synthesize new heterocyclic Schiff bases derived from 2-amino-3-formylchromone and investigate their antimicrobial activity. The study focused on combining chromone moieties with 1,2,4-triazole or 1,2,4-triazine derivatives through an azomethine linkage to create novel nitrogen heterocyclic systems. Key chemicals used included 2-amino-3-formylchromone as the starting material, various hydrazine derivatives (such as benzoylhydrazine, cyanoacetohydrazide, and thiocarbohydrazide) for condensation reactions, and electrophilic reagents like benzoyl chloride, acetic anhydride, and carbon disulfide for further heterocyclization. The newly synthesized compounds were characterized using IR, 1H NMR, and mass spectrometry. The antimicrobial activity of these compounds was tested against a range of bacteria and fungi, revealing that compounds 8 and 20 showed moderate activity against bacteria and high activity against fungi, while compounds 9, 13, and 15 exhibited high antifungal activity. The study concluded that the synthesized compounds have potential as antimicrobial agents, particularly those incorporating dithioxo-1,2,4-triazole and antipyrine moieties, and suggested that further modifications could enhance their biological efficacy.
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