Technology Process of 1-Benzoxepin-7-carboxylic acid,
2,3,4,5-tetrahydro-3-methylene-5-(phenylmethyl)-5-(phenylsulfonyl)-,
methyl ester
There total 3 articles about 1-Benzoxepin-7-carboxylic acid,
2,3,4,5-tetrahydro-3-methylene-5-(phenylmethyl)-5-(phenylsulfonyl)-,
methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-benzenesulfonyl-3-methylene-2,3,4,5-tetrahydrobenzo[b]oxepine-7-carboxylic acid methyl ester;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 20 ℃;
for 0.25h;
benzyl bromide;
In
tetrahydrofuran;
at 20 ℃;
for 0.0833333h;
Further stages.;
DOI:10.1039/b306356a
- Guidance literature:
-
3-benzenesulfonyl-4-(2-chloromethylallyloxy)benzoic acid methyl ester;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 20 ℃;
for 0.25h;
benzyl bromide;
In
tetrahydrofuran;
at 20 ℃;
for 0.0833333h;
Further stages.;
DOI:10.1039/b306356a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 50 percent / n-Bu4NI; K2CO3 / dimethylformamide / 20 h / 20 °C
2.1: DMPU; LHMDS / tetrahydrofuran / 0.25 h / 20 °C
2.2: 61 percent / tetrahydrofuran / 0.08 h / 20 °C
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetra-(n-butyl)ammonium iodide; potassium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/b306356a
