Cyclohexaneacetic acid, 2-oxo-, phenylmethyl ester

Base Information

• Chemical Name: Cyclohexaneacetic acid, 2-oxo-, phenylmethyl ester
• CAS No.: 497968-19-1
• Molecular Formula: C15H18O3
• Molecular Weight: 246.306
• Mol file: 497968-19-1.mol

Synonyms:

Chemical Property of Cyclohexaneacetic acid, 2-oxo-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexaneacetic acid, 2-oxo-, phenylmethyl ester

There total 7 articles about Cyclohexaneacetic acid, 2-oxo-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + benzyl diazoacetate (52267-51-3) → dibenzyl 2,2'-(2-oxocyclohexane-1,3-diyl)diacetate + 2-(benzyloxycarbonylmethyl)cyclohexanone (497968-19-1)

Guidance literature:

With pyrrolidine; 5,10,15,20-tetrakis(4-methoxycarbonylphenyl)porphyrin; In aq. phosphate buffer; dimethyl sulfoxide; at 25 ℃; for 7h; pH=4; Irradiation; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201800542

Reference yield: 77.0%

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + Benzyl bromoacetate (5437-45-6) → 2-(benzyloxycarbonylmethyl)cyclohexanone (497968-19-1)

Guidance literature:

With tris(dimethylamino)sulfonium trimethylsilyldifluoride; In tetrahydrofuran; at -78 - 22 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo4018099

Reference yield: 70.0%

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + benzyl iodoacetate (81867-37-0) → 2-(benzyloxycarbonylmethyl)cyclohexanone (497968-19-1)

Guidance literature:

1-(Trimethylsilyloxy)cyclohexene; With methyllithium; In diethyl ether; at 0 ℃; for 0.5h;

With gallium(III) trichloride; In diethyl ether; hexane; at 0 - 20 ℃; for 0.5h;

benzyl iodoacetate; With air; triethyl borane; In diethyl ether; hexane; at 25 ℃; for 3h;

DOI:10.1246/bcsj.75.2049

upstream raw materials:

1-(Trimethylsilyloxy)cyclohexene

benzyl iodoacetate

Benzyl bromoacetate

cyclohexanone

Downstream raw materials:

6-(benzyloxycarbonylmethyl)-ε-caprolactone

2-(benzyloxycarbonylmethyl)-ε-caprolactone

(2R)-N-(2-(1,5-dioxaspiro[5.5]undecan-7-yl)ethyl)-2-phenylbut-3-en-1-amine

2-((3aS,7aR)-1-(benzyloxycarbonyl)octahydro-1H-indol-7a-yl)acetic acid